Mechanics of the mitral valve: In vitro studies

Jorge H. Jimenez, Jennifer Ritchie, Zhaoming He, Ajit P. Yoganathan

Research output: Contribution to journalConference articlepeer-review

4 Scopus citations


Improved knowledge of mitral valve (MV) mechanics is essential to understanding normal MV function and design; however, there is limited information about the mechanical properties of the MV during physiologic loading. These studies utilized different techniques to characterize the mechanical properties of the MV. Histological techniques were used to examine collagen, elastin, and cellular distribution on the chordae. Vessels were observed in both the longitudinal and circumferential directions. The presence of vessels characterize the chordae as complex living components that must work with the PM and MV leaflets to prevent MV prolapse and regurgitation. Force and strain distribution on the chordae and anterior leaflet were measured in a physiologic left heart simulator under physiological and pathological papillary muscle (PM) positions. Tension distribution results showed that the intermediate chords held significantly larger loads than the marginal chords on their respective leaflets. The slack PM position led to a delay in complete valve closure and more rapid leaflet loading in late systole. The chordae showed physiological strains, reaching maximum strain during valve closure. The in vitro studies demonstrated that chordal force distribution and valve function depend on the mechanical environment of the valve and the geometric relationships between its components.

Original languageEnglish
Pages (from-to)3727-3729
Number of pages3
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume26 V
StatePublished - 2004
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004


  • Chordae tendineae
  • Mitral valve
  • Mitral valve mechanics


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