Maternal separation followed by isolation-housing differentially affects prepulse inhibition of the acoustic startle response in C57BL/6 mice

Jeremy D. Bailoo, Justin A. Varholick, Xavier J. Garza, Richard L. Jordan, Sara Hintze

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Exposure to chronic stress is associated with an increased incidence of neuropsychiatric dysfunction. The current study evaluated two competing hypotheses, the cumulative stress and the match/mismatch hypothesis of neuropsychiatric dysfunction, using two paradigms relating to exposure to “stress”: pre-weaning maternal separation and post-weaning isolation-housing. C57BL/6 offspring were reared under four conditions: typical animal facility rearing (AFR, control), early handling (EH, daily 15 min separation from dam), maternal separation (MS, daily 4 hr separation from dam), and maternal and peer separation (MPS, daily 4 hr separation from dam and from littermates). After weaning, mice were either housed socially (2–3/cage) or in isolation (1/cage) and then tested for prepulse inhibition in adulthood. Isolation-housed MPS subjects displayed greater deficits in prepulse inhibition relative to socially-housed MPS subjects while socially-housed AFR subjects displayed greater deficits in prepulse inhibition relative to isolation-housed AFR subjects. The results indicate that these treatment conditions represent a potentially valuable model for evaluating the match/mismatch hypothesis in regards to neuropsychiatric dysfunction.

Original languageEnglish
Pages (from-to)937-944
Number of pages8
JournalDevelopmental psychobiology
Volume58
Issue number8
DOIs
StatePublished - Dec 1 2016

Keywords

  • early handling
  • isolation-housing
  • match/mismatch hypothesis
  • maternal separation
  • prepulse inhibition

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