Manoyl oxide α-arabinopyranoside and grindelic acid diterpenoids from Grindelia integrifolia

A. A. Ahmed; A. A. Mahmoud; U. M. Ahmed; A. A. El-Bassuony; M. H. Abd El-Razk; P. W. Pare; J. Karchesy

doi:10.1021/np010273n

Manoyl oxide α-arabinopyranoside and grindelic acid diterpenoids from Grindelia integrifolia

A. A. Ahmed, A. A. Mahmoud, U. M. Ahmed, A. A. El-Bassuony, M. H. Abd El-Razk, P. W. Pare, J. Karchesy

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Two new manoyl oxide-α-arabinopyranoside diterpenoids, 15-hydroxy-13-epi-manoyl oxide-14-O-α-L-arabinopyranoside (tarapacol-14-O-α-L-arabinopyranoside) (1) and 15-acetoxy-13-epi-manoyl oxide-14-O-α-L-arabinopyranoside (tarapacol-15-acetate-14-O-α-L-arabinopyranoside) (2), as well as a new grindelic acid derivative, 19-hydroxygrindelic acid (3), together with five known diterpenoids (tarapacol, tarapacanol A, grindelic acid, methyl grindeloate, 3β-hydroxygrindelic acid, 4) were isolated from the aerial parts of Grindelia integrifolia. The structures of 1-3 were elucidated by spectral data analysis.

Original language	English
Pages (from-to)	1365-1367
Number of pages	3
Journal	Journal of Natural Products
Volume	64
Issue number	10
DOIs	https://doi.org/10.1021/np010273n
State	Published - 2001

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@article{7b3adfba59da44a7b74cdda4dd734691,

title = "Manoyl oxide α-arabinopyranoside and grindelic acid diterpenoids from Grindelia integrifolia",

abstract = "Two new manoyl oxide-α-arabinopyranoside diterpenoids, 15-hydroxy-13-epi-manoyl oxide-14-O-α-L-arabinopyranoside (tarapacol-14-O-α-L-arabinopyranoside) (1) and 15-acetoxy-13-epi-manoyl oxide-14-O-α-L-arabinopyranoside (tarapacol-15-acetate-14-O-α-L-arabinopyranoside) (2), as well as a new grindelic acid derivative, 19-hydroxygrindelic acid (3), together with five known diterpenoids (tarapacol, tarapacanol A, grindelic acid, methyl grindeloate, 3β-hydroxygrindelic acid, 4) were isolated from the aerial parts of Grindelia integrifolia. The structures of 1-3 were elucidated by spectral data analysis.",

author = "Ahmed, {A. A.} and Mahmoud, {A. A.} and Ahmed, {U. M.} and El-Bassuony, {A. A.} and {Abd El-Razk}, {M. H.} and Pare, {P. W.} and J. Karchesy",

year = "2001",

doi = "10.1021/np010273n",

language = "English",

volume = "64",

pages = "1365--1367",

journal = "Journal of Natural Products",

issn = "0163-3864",

number = "10",

}

TY - JOUR

T1 - Manoyl oxide α-arabinopyranoside and grindelic acid diterpenoids from Grindelia integrifolia

AU - Ahmed, A. A.

AU - Mahmoud, A. A.

AU - Ahmed, U. M.

AU - El-Bassuony, A. A.

AU - Abd El-Razk, M. H.

AU - Pare, P. W.

AU - Karchesy, J.

PY - 2001

Y1 - 2001

N2 - Two new manoyl oxide-α-arabinopyranoside diterpenoids, 15-hydroxy-13-epi-manoyl oxide-14-O-α-L-arabinopyranoside (tarapacol-14-O-α-L-arabinopyranoside) (1) and 15-acetoxy-13-epi-manoyl oxide-14-O-α-L-arabinopyranoside (tarapacol-15-acetate-14-O-α-L-arabinopyranoside) (2), as well as a new grindelic acid derivative, 19-hydroxygrindelic acid (3), together with five known diterpenoids (tarapacol, tarapacanol A, grindelic acid, methyl grindeloate, 3β-hydroxygrindelic acid, 4) were isolated from the aerial parts of Grindelia integrifolia. The structures of 1-3 were elucidated by spectral data analysis.

AB - Two new manoyl oxide-α-arabinopyranoside diterpenoids, 15-hydroxy-13-epi-manoyl oxide-14-O-α-L-arabinopyranoside (tarapacol-14-O-α-L-arabinopyranoside) (1) and 15-acetoxy-13-epi-manoyl oxide-14-O-α-L-arabinopyranoside (tarapacol-15-acetate-14-O-α-L-arabinopyranoside) (2), as well as a new grindelic acid derivative, 19-hydroxygrindelic acid (3), together with five known diterpenoids (tarapacol, tarapacanol A, grindelic acid, methyl grindeloate, 3β-hydroxygrindelic acid, 4) were isolated from the aerial parts of Grindelia integrifolia. The structures of 1-3 were elucidated by spectral data analysis.

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U2 - 10.1021/np010273n

DO - 10.1021/np010273n

M3 - Article

C2 - 11678671

AN - SCOPUS:0034752577

VL - 64

SP - 1365

EP - 1367

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 10

ER -