TY - JOUR
T1 - Mannogen-ing Central Carbon Metabolism by Leishmania
AU - Zhang, Kai
AU - Beverley, Stephen M.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/12
Y1 - 2019/12
N2 - Leishmania parasites synthesize mannogens, a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al. The crucial roles of mannogen in regulating central carbon metabolism and in vivo virulence suggest the potential of MTPs as promising drug targets.
AB - Leishmania parasites synthesize mannogens, a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al. The crucial roles of mannogen in regulating central carbon metabolism and in vivo virulence suggest the potential of MTPs as promising drug targets.
KW - dual-activity mannosyltransferase/phosphorylase
KW - horizontal gene transfer
KW - reservoir carbohydrate
KW - trypanosomatid protozoan parasite
KW - virulence
UR - http://www.scopus.com/inward/record.url?scp=85074409595&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2019.10.001
DO - 10.1016/j.pt.2019.10.001
M3 - Short survey
C2 - 31662278
AN - SCOPUS:85074409595
SN - 1471-4922
VL - 35
SP - 947
EP - 949
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 12
ER -