Abstract
Manganese (IV) oxide was found to catalyze the diamination reaction of α,β-unsaturated esters and ketones with N,N-dichloro-p- toluenesulfonamide and acetonitrile as the halogen and nitrogen sources. The reaction is convenient to be conducted by simply mixing three reactants in the presence of manganese dioxide catalyst and 4 Å molecular sieves, and provides an easy access to 1-p-toluenesulfonyl-3-trichloromethyl-4,5-imidazoline derivatives, which are useful building blocks for peptidomimetic studies.
Original language | English |
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Pages (from-to) | 249-254 |
Number of pages | 6 |
Journal | Journal of Peptide Research |
Volume | 66 |
Issue number | 5 |
DOIs | |
State | Published - Nov 2005 |
Keywords
- Alkene addition
- Diamine
- Diamino acid
- Imidazoline
- Manganese (IV) oxide