Male antigen defined serologically does not identify a factor responsible for testicular development

Ellen H. Goldberg; Anne McLaren; Brian Reilly

doi:10.1016/0165-0378(91)90055-U

Male antigen defined serologically does not identify a factor responsible for testicular development

Ellen H. Goldberg, Anne McLaren, Brian Reilly

Biological Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

To test the proposal that the serologically detected male antigen (SDMA; which may or may not be the same as H-Y) was responsible for triggering the indifferent gonad to differentiate into the testis in mammals, H-Y negative sex-reversed XXSxr' male mice were investigated for the presence of SDMA. Serum from C57BL/6 female mice immunized against tissue from XXSxr' males did not contain SDMA specific antibody as detected by the complement-mediated sperm cytotoxicity assay. Thus, although SDMA is a male-specific factor and may play a role in male sex determination, it does not identify the testis-determining factor (TDF).

Original language	English
Pages (from-to)	305-309
Number of pages	5
Journal	Journal of Reproductive Immunology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0165-0378(91)90055-U
State	Published - Sep 1991

Keywords

(SDMA)
XXSxr' male mice
serologically detected male antigen

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10.1016/0165-0378(91)90055-U

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title = "Male antigen defined serologically does not identify a factor responsible for testicular development",

abstract = "To test the proposal that the serologically detected male antigen (SDMA; which may or may not be the same as H-Y) was responsible for triggering the indifferent gonad to differentiate into the testis in mammals, H-Y negative sex-reversed XXSxr' male mice were investigated for the presence of SDMA. Serum from C57BL/6 female mice immunized against tissue from XXSxr' males did not contain SDMA specific antibody as detected by the complement-mediated sperm cytotoxicity assay. Thus, although SDMA is a male-specific factor and may play a role in male sex determination, it does not identify the testis-determining factor (TDF).",

keywords = "(SDMA), XXSxr' male mice, serologically detected male antigen",

author = "Goldberg, {Ellen H.} and Anne McLaren and Brian Reilly",

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AU - Goldberg, Ellen H.

AU - McLaren, Anne

AU - Reilly, Brian

PY - 1991/9

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N2 - To test the proposal that the serologically detected male antigen (SDMA; which may or may not be the same as H-Y) was responsible for triggering the indifferent gonad to differentiate into the testis in mammals, H-Y negative sex-reversed XXSxr' male mice were investigated for the presence of SDMA. Serum from C57BL/6 female mice immunized against tissue from XXSxr' males did not contain SDMA specific antibody as detected by the complement-mediated sperm cytotoxicity assay. Thus, although SDMA is a male-specific factor and may play a role in male sex determination, it does not identify the testis-determining factor (TDF).

AB - To test the proposal that the serologically detected male antigen (SDMA; which may or may not be the same as H-Y) was responsible for triggering the indifferent gonad to differentiate into the testis in mammals, H-Y negative sex-reversed XXSxr' male mice were investigated for the presence of SDMA. Serum from C57BL/6 female mice immunized against tissue from XXSxr' males did not contain SDMA specific antibody as detected by the complement-mediated sperm cytotoxicity assay. Thus, although SDMA is a male-specific factor and may play a role in male sex determination, it does not identify the testis-determining factor (TDF).

KW - (SDMA)

KW - XXSxr' male mice

KW - serologically detected male antigen

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EP - 309

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ER -

Male antigen defined serologically does not identify a factor responsible for testicular development

Abstract

Keywords

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