Male antigen defined serologically does not identify a factor responsible for testicular development

Ellen H. Goldberg, Anne McLaren, Brian Reilly

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

To test the proposal that the serologically detected male antigen (SDMA; which may or may not be the same as H-Y) was responsible for triggering the indifferent gonad to differentiate into the testis in mammals, H-Y negative sex-reversed XXSxr' male mice were investigated for the presence of SDMA. Serum from C57BL/6 female mice immunized against tissue from XXSxr' males did not contain SDMA specific antibody as detected by the complement-mediated sperm cytotoxicity assay. Thus, although SDMA is a male-specific factor and may play a role in male sex determination, it does not identify the testis-determining factor (TDF).

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalJournal of Reproductive Immunology
Volume20
Issue number3
DOIs
StatePublished - Sep 1991

Keywords

  • (SDMA)
  • XXSxr' male mice
  • serologically detected male antigen

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