TY - JOUR
T1 - Maintenance of behavior by ketamine and related compounds in rhesus monkeys with different self-administration histories
AU - Young, A. M.
AU - Woods, J. H.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1981
Y1 - 1981
N2 - Rhesus monkeys lever-pressed under a fixed-ratio 30 time-out 600 sec schedule of i.v. injection of codeine (0.32 mg/kg/injection) or, in a second group of monkeys, ketamine (1.0 mg/kg/injection). During single session substitutions, the maintenance drug was replaced with saline or doses of various other drugs. At appropriate doses, ketamine maintained responding when substituted for codeine and codeine maintained responding when substituted for ketamine. Phencyclidine, dexoxadrol and dextrorphan maintained responding when substituted for ketamine but did not maintain responding when substituted for codeine. Cyclozocine and SKF-10,047 (N-allyl-nor-metazocine) did not maintain responding when substituted for either ketamine or codeine: ethylketazocine did not maintain responding when substituted for ketamine. For those drugs that maintained behavior, fixed-ratio response rate and the number of injections increased to a maximum value with increasing injection dose and then decreased at higher injection doses. Substituted drugs maintained maximum response rates at the following injection doses: codeine, 0.32 mg/kg: ketamine, 1.0 mg/kg: phencyclidine, 0.03 mg/kg, dexoxadrol, 0.32 mg/kg: and dextrorphan, 1.0 mg/kg. Under only the ketamine maintenance schedule, the rate of responding during the timeout component varied as a function of the substitution dose of ketamine, codeine, phencyclidine and dexoxadrol, with the dose that maintained maximal fixed-ratio rates also engendering the highest rates of timeout responding.
AB - Rhesus monkeys lever-pressed under a fixed-ratio 30 time-out 600 sec schedule of i.v. injection of codeine (0.32 mg/kg/injection) or, in a second group of monkeys, ketamine (1.0 mg/kg/injection). During single session substitutions, the maintenance drug was replaced with saline or doses of various other drugs. At appropriate doses, ketamine maintained responding when substituted for codeine and codeine maintained responding when substituted for ketamine. Phencyclidine, dexoxadrol and dextrorphan maintained responding when substituted for ketamine but did not maintain responding when substituted for codeine. Cyclozocine and SKF-10,047 (N-allyl-nor-metazocine) did not maintain responding when substituted for either ketamine or codeine: ethylketazocine did not maintain responding when substituted for ketamine. For those drugs that maintained behavior, fixed-ratio response rate and the number of injections increased to a maximum value with increasing injection dose and then decreased at higher injection doses. Substituted drugs maintained maximum response rates at the following injection doses: codeine, 0.32 mg/kg: ketamine, 1.0 mg/kg: phencyclidine, 0.03 mg/kg, dexoxadrol, 0.32 mg/kg: and dextrorphan, 1.0 mg/kg. Under only the ketamine maintenance schedule, the rate of responding during the timeout component varied as a function of the substitution dose of ketamine, codeine, phencyclidine and dexoxadrol, with the dose that maintained maximal fixed-ratio rates also engendering the highest rates of timeout responding.
UR - http://www.scopus.com/inward/record.url?scp=0019377512&partnerID=8YFLogxK
M3 - Article
C2 - 7264955
AN - SCOPUS:0019377512
VL - 218
SP - 720
EP - 727
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
SN - 0022-3565
IS - 3
ER -