Magnetic drug targeting simulations in blood flows with fluid-structure interaction

Sara Calandrini, Giacomo Capodaglio, Eugenio Aulisa

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We present fluid-structure interaction simulations of magnetic drug targeting (MDT) in blood flows. In this procedure, a drug is attached to ferromagnetic particles to externally direct it to a specific target after it is injected inside the body. The goal is to minimize the healthy tissue affected by the treatment and to maximize the number of particles that reach the target location. Magnetic drug targeting has been studied both experimentally and theoretically by several authors. In recent years, computational fluid dynamics simulations of MDT in blood flows have been conducted to obtain further insight on the combination of parameters that provide the best capture efficiency. However, to this day, no computational study addressed MDT in a fluid-structure interaction setting. With this paper, we aim to fill this gap and investigate the impact of the solid deformation on the capture efficiency.

Original languageEnglish
Article numbere2954
JournalInternational Journal for Numerical Methods in Biomedical Engineering
Volume34
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • blood flow
  • fluid-structure interaction
  • magnetic drug targeting
  • particle tracking

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