TY - JOUR
T1 - Lost in translation
T2 - Ribosome-associated mRNA and protein quality controls
AU - Karamyshev, Andrey L.
AU - Karamysheva, Zemfira N.
N1 - Funding Information:
This work was supported by the Start-up funds from Texas Tech University Health Sciences Center and by the National Institute of Neurological Disorders and Stroke of the National
Publisher Copyright:
© 2018 Karamyshev and Karamysheva.
PY - 2018/10/4
Y1 - 2018/10/4
N2 - Aberrant, misfolded, and mislocalized proteins are often toxic to cells and result in many human diseases. All proteins and their mRNA templates are subject to quality control. There are several distinct mechanisms that control the quality of mRNAs and proteins during translation at the ribosome. mRNA quality control systems, nonsensemediated decay, non-stop decay, and no-go decay detect premature stop codons, the absence of a natural stop codon, and stalled ribosomes in translation, respectively, and degrade their mRNAs. Defective truncated polypeptide nascent chains generated from faulty mRNAs are degraded by ribosome-associated protein quality control pathways. Regulation of aberrant protein production, a novel pathway, senses aberrant proteins by monitoring the status of nascent chain interactions during translation and triggers degradation of their mRNA. Here, we review the current progress in understanding of the molecular mechanisms of mRNA and protein quality controls at the ribosome during translation.
AB - Aberrant, misfolded, and mislocalized proteins are often toxic to cells and result in many human diseases. All proteins and their mRNA templates are subject to quality control. There are several distinct mechanisms that control the quality of mRNAs and proteins during translation at the ribosome. mRNA quality control systems, nonsensemediated decay, non-stop decay, and no-go decay detect premature stop codons, the absence of a natural stop codon, and stalled ribosomes in translation, respectively, and degrade their mRNAs. Defective truncated polypeptide nascent chains generated from faulty mRNAs are degraded by ribosome-associated protein quality control pathways. Regulation of aberrant protein production, a novel pathway, senses aberrant proteins by monitoring the status of nascent chain interactions during translation and triggers degradation of their mRNA. Here, we review the current progress in understanding of the molecular mechanisms of mRNA and protein quality controls at the ribosome during translation.
KW - Post-transcriptional regulation of gene expression
KW - Protein quality control
KW - Protein targeting and folding
KW - RNA degradation
KW - RNA quality control
KW - RNA stability
KW - Ribosome
KW - Translation
UR - http://www.scopus.com/inward/record.url?scp=85055327332&partnerID=8YFLogxK
U2 - 10.3389/fgene.2018.00431
DO - 10.3389/fgene.2018.00431
M3 - Review article
AN - SCOPUS:85055327332
VL - 9
JO - Frontiers in Genetics
JF - Frontiers in Genetics
SN - 1664-8021
IS - OCT
M1 - 431
ER -