TY - JOUR
T1 - Loading effects on the performance of needle-free jet injections in different skin models
AU - Rohilla, Pankaj
AU - Lawal, Idera
AU - Le Blanc, Andrew
AU - O'Brien, Veronica
AU - Weeks, Cormak
AU - Tran, Whitney
AU - Rane, Yatish
AU - Khusnatdinov, Emil
AU - Marston, Jeremy
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/12
Y1 - 2020/12
N2 - Intradermal delivery of vaccines with jet injection is one of the alternatives to conventional delivery techniques with hypodermic needles via the Mantoux technique and multi-puncture devices etc. However, for a given fluid, the effects of various parameters related to injector design, as well as skin properties are still not well understood. While the key design parameters are orifice diameter, jet speed, cartridge volume, and standoff distance, we must also consider the applied load of the device on the skin and axial skin tension. These parameters are all studied herein using different ex vivo models (guinea pig, pig, and human skin) and different fluid viscosities. We find that the applied load can have a significant effect on the amount of drug delivered through the skin, as well as the fluid dispersion pattern in the intradermal tissues. Regardless of skin type or fluid viscosity, we show that minimal standoff and applied force loads of approximately 1 kg (9.81 N) should be used to maximize injection efficiency when targeting intradermal tissue with the spring-powered device used in this study.
AB - Intradermal delivery of vaccines with jet injection is one of the alternatives to conventional delivery techniques with hypodermic needles via the Mantoux technique and multi-puncture devices etc. However, for a given fluid, the effects of various parameters related to injector design, as well as skin properties are still not well understood. While the key design parameters are orifice diameter, jet speed, cartridge volume, and standoff distance, we must also consider the applied load of the device on the skin and axial skin tension. These parameters are all studied herein using different ex vivo models (guinea pig, pig, and human skin) and different fluid viscosities. We find that the applied load can have a significant effect on the amount of drug delivered through the skin, as well as the fluid dispersion pattern in the intradermal tissues. Regardless of skin type or fluid viscosity, we show that minimal standoff and applied force loads of approximately 1 kg (9.81 N) should be used to maximize injection efficiency when targeting intradermal tissue with the spring-powered device used in this study.
KW - Jet
KW - Needle-free
KW - Transdermal
KW - Viscosity
UR - http://www.scopus.com/inward/record.url?scp=85090744358&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2020.102043
DO - 10.1016/j.jddst.2020.102043
M3 - Article
AN - SCOPUS:85090744358
SN - 1773-2247
VL - 60
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 102043
ER -