Liquid chromatography/electrospray ionization tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)

Xiaoping Pan; Baohong Zhang; Kang Tian; Lindsey E. Jones; Jun Liu; Todd A. Anderson; Jia Sheng Wang; George P. Cobb

doi:10.1002/rcm.2576

Liquid chromatography/electrospray ionization tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)

Xiaoping Pan, Baohong Zhang, Kang Tian, Lindsey E. Jones, Jun Liu, Todd A. Anderson, Jia Sheng Wang, George P. Cobb

Environmental Toxicology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A quantitative liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method was developed for the analysis of the explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). In negative ionization mode, HMX forms an acetate adduct ion [M + CH₃COO] ^-, m/z 355, in the presence of a small amount of acetic acid in the mobile phase. The ESI collision-induced dissociation (CID) spectrum of m/z 355 was acquired and the transitions m/z 355 → 147 and m/z 355 → 174 were chosen for the determination of HMX in samples. Using this quantification technique, the method detection limit was 1.57 μg/L and good linearity was achieved in the range 5-500 μg/L. This method will help to unambiguously analyze environmentally relevant concentrations of HMX.

Original language	English
Pages (from-to)	2222-2226
Number of pages	5
Journal	Rapid Communications in Mass Spectrometry
Volume	20
Issue number	14
DOIs	https://doi.org/10.1002/rcm.2576
State	Published - 2006

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10.1002/rcm.2576

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@article{440b76acd2e84540ade7a3cfa6a1fcbc,

title = "Liquid chromatography/electrospray ionization tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)",

abstract = "A quantitative liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method was developed for the analysis of the explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). In negative ionization mode, HMX forms an acetate adduct ion [M + CH3COO] -, m/z 355, in the presence of a small amount of acetic acid in the mobile phase. The ESI collision-induced dissociation (CID) spectrum of m/z 355 was acquired and the transitions m/z 355 → 147 and m/z 355 → 174 were chosen for the determination of HMX in samples. Using this quantification technique, the method detection limit was 1.57 μg/L and good linearity was achieved in the range 5-500 μg/L. This method will help to unambiguously analyze environmentally relevant concentrations of HMX.",

author = "Xiaoping Pan and Baohong Zhang and Kang Tian and Jones, {Lindsey E.} and Jun Liu and Anderson, {Todd A.} and Wang, {Jia Sheng} and Cobb, {George P.}",

year = "2006",

doi = "10.1002/rcm.2576",

language = "English",

volume = "20",

pages = "2222--2226",

journal = "Rapid Communications in Mass Spectrometry",

issn = "0951-4198",

number = "14",

}

TY - JOUR

T1 - Liquid chromatography/electrospray ionization tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)

AU - Pan, Xiaoping

AU - Zhang, Baohong

AU - Tian, Kang

AU - Jones, Lindsey E.

AU - Liu, Jun

AU - Anderson, Todd A.

AU - Wang, Jia Sheng

AU - Cobb, George P.

PY - 2006

Y1 - 2006

N2 - A quantitative liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method was developed for the analysis of the explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). In negative ionization mode, HMX forms an acetate adduct ion [M + CH3COO] -, m/z 355, in the presence of a small amount of acetic acid in the mobile phase. The ESI collision-induced dissociation (CID) spectrum of m/z 355 was acquired and the transitions m/z 355 → 147 and m/z 355 → 174 were chosen for the determination of HMX in samples. Using this quantification technique, the method detection limit was 1.57 μg/L and good linearity was achieved in the range 5-500 μg/L. This method will help to unambiguously analyze environmentally relevant concentrations of HMX.

AB - A quantitative liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method was developed for the analysis of the explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). In negative ionization mode, HMX forms an acetate adduct ion [M + CH3COO] -, m/z 355, in the presence of a small amount of acetic acid in the mobile phase. The ESI collision-induced dissociation (CID) spectrum of m/z 355 was acquired and the transitions m/z 355 → 147 and m/z 355 → 174 were chosen for the determination of HMX in samples. Using this quantification technique, the method detection limit was 1.57 μg/L and good linearity was achieved in the range 5-500 μg/L. This method will help to unambiguously analyze environmentally relevant concentrations of HMX.

UR - http://www.scopus.com/inward/record.url?scp=33745904478&partnerID=8YFLogxK

U2 - 10.1002/rcm.2576

DO - 10.1002/rcm.2576

M3 - Article

C2 - 16791873

AN - SCOPUS:33745904478

SN - 0951-4198

VL - 20

SP - 2222

EP - 2226

JO - Rapid Communications in Mass Spectrometry

JF - Rapid Communications in Mass Spectrometry

IS - 14

ER -

Liquid chromatography/electrospray ionization tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)

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