Ligand-Enabled δ-C(sp3)−H Borylation of Aliphatic Amines

Hediyala B. Chandrashekar, Pravas Dolui, Bijin Li, Astam Mandal, Hao Liu, Srimanta Guin, Haibo Ge, Debabrata Maiti

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Directed C−H functionalization has been realized as a complimentary technique to achieve borylation at a distal position of aliphatic amines. Here, we demonstrated the oxidative borylation at the distal δ-position of aliphatic amines using various borylating agents, a palladium catalyst, and a rightly tuned ligand in the presence of a cheap oxidant. Moreover, an organopalladium δ-C(sp3)-H-activated intermediate has been isolated and crystallographically characterized to get mechanistic insight.

Original languageEnglish
Pages (from-to)18194-18200
Number of pages7
JournalAngewandte Chemie - International Edition
Volume60
Issue number33
DOIs
StatePublished - Aug 9 2021

Keywords

  • C−H activation
  • Pd catalysis
  • mechanistic studies
  • δ-borylation

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