Leukocyte-Reduced Platelet-Rich Plasma Normalizes Matrix Metabolism in Torn Human Rotator Cuff Tendons

J Cross, Brian Cole, K Spatny, Emily Sundman, A Romeo, G Nicholson, B Wagner, Lisa Fortier

Research output: Contribution to journalArticlepeer-review

Abstract

<b>Background:</b> The optimal platelet-rich plasma (PRP) for treatment of supraspinatus tendinopathy has not been determined. <br> <b>Purpose:</b> To evaluate the effect of low- versus high-leukocyte concentrated PRP products on catabolic and anabolic mediators of matrix metabolism in diseased rotator cuff tendons. <br> <b>Study design:</b> Controlled laboratory study. <br> <b>Methods:</b> Diseased supraspinatus tendons were treated with PRP made by use of 2 commercial systems: Arthrex Autologous Conditioned Plasma Double Syringe System (L(lo) PRP) and Biomet GPS III Mini Platelet Concentrate System (L(hi) PRP). Tendon explants were placed in 6-well plates and cultured in L(lo) PRP, L(hi) PRP, or control media (Dulbecco's Modified Eagle Medium + 10% fetal bovine serum) for 96 hours. Tendo
Original languageEnglish
Pages (from-to)2898-2906
JournalAmerican Journal of Sports Medicine
StatePublished - Dec 2015

Fingerprint Dive into the research topics of 'Leukocyte-Reduced Platelet-Rich Plasma Normalizes Matrix Metabolism in Torn Human Rotator Cuff Tendons'. Together they form a unique fingerprint.

Cite this