TY - JOUR
T1 - Left-dominant temporal-frontal hypercoupling in schizophrenia patients with hallucinations during speech perception
AU - Lavigne, Katie M.
AU - Rapin, Lucile A.
AU - Metzak, Paul D.
AU - Whitman, Jennifer C.
AU - Jung, Kwanghee
AU - Dohen, Marion
AU - Lœvenbruck, Hélène
AU - Woodward, Todd S.
N1 - Publisher Copyright:
© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background: Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. Methods: In the current study, we used a task that allowed experimental manipulation of control over verbal material and compared brain activity between 23 schizophrenia patients (10 hallucinators, 13 nonhallucinators), 22 psychiatric (bipolar), and 27 healthy controls. Two conditions were presented, one involving inner verbal thought (in which control over verbal material was required) and another involving speech perception (SP; in which control verbal material was not required). Results: A functional connectivity analysis resulted in a left-dominant temporal-frontal network that included speech-related auditory and motor regions and showed hypercoupling in past-week hallucinating schizophrenia patients (relative to nonhallucinating patients) during SP only. Conclusions: These findings replicate our previous work showing generalized speech-related functional network hypercoupling in schizophrenia during inner verbal thought and SP, but extend them by suggesting that hypercoupling is related to past-week hallucination severity scores during SP only, when control over verbal material is not required. This result opens the possibility that practicing control over inner verbal thought processes may decrease the likelihood or severity of hallucinations.
AB - Background: Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. Methods: In the current study, we used a task that allowed experimental manipulation of control over verbal material and compared brain activity between 23 schizophrenia patients (10 hallucinators, 13 nonhallucinators), 22 psychiatric (bipolar), and 27 healthy controls. Two conditions were presented, one involving inner verbal thought (in which control over verbal material was required) and another involving speech perception (SP; in which control verbal material was not required). Results: A functional connectivity analysis resulted in a left-dominant temporal-frontal network that included speech-related auditory and motor regions and showed hypercoupling in past-week hallucinating schizophrenia patients (relative to nonhallucinating patients) during SP only. Conclusions: These findings replicate our previous work showing generalized speech-related functional network hypercoupling in schizophrenia during inner verbal thought and SP, but extend them by suggesting that hypercoupling is related to past-week hallucination severity scores during SP only, when control over verbal material is not required. This result opens the possibility that practicing control over inner verbal thought processes may decrease the likelihood or severity of hallucinations.
KW - functional connectivity
KW - functional magnetic resonance imaging
KW - inner speech
KW - schizophrenia
KW - speech perception
UR - http://www.scopus.com/inward/record.url?scp=84926357799&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbu004
DO - 10.1093/schbul/sbu004
M3 - Article
C2 - 24553150
AN - SCOPUS:84926357799
SN - 0586-7614
VL - 41
SP - 259
EP - 267
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 1
ER -