TY - JOUR
T1 - Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: A matched control study
T2 - A matched-control study
AU - Alqahtani, A R
AU - Elahmedi, M O
AU - Lee, Jae Hoon
AU - Butler, M G
AU - Al Qahtani, Awadh R.
N1 - Funding Information:
This project was financially supported by King Saud University, through the Vice Deanship of Research Chairs and the Deanship of Scientific Research through research group number RGP-VPP-186. The authors also acknowledge the contribution from Shaikh Ali Alshehri Obesity Chair for supporting the clinic services and team members Ms. Nesma M. Mustafa and Ms. Layla Alfarra for collection of the relevant data during follow-up sessions. They also thank the participants who took part in the multidisciplinary program.
Publisher Copyright:
© 2016 American Society for Metabolic and Bariatric Surgery. All rights reserved.
PY - 2016/1
Y1 - 2016/1
N2 - Background: Obesity is a leading cause of mortality and morbidity in Prader-Willi syndrome (PWS). Objectives: To study weight loss and growth after laparoscopic sleeve gastrectomy (LSG) in pediatric patients with PWS compared with those without the syndrome. Setting: Academic center with a standardized care pathway for pediatric bariatric surgery as a part of a prospective clinical outcome study on children and adolescents undergoing weight loss surgery. Methods: Clinical data of all PWS patients who underwent LSG were abstracted from our prospective database, which included all pediatric patients who underwent bariatric surgery. These data were then compared with a 1:3 non-PWS group matched for age, gender, and body mass index (BMI). Data for up to 5 years follow-up were analyzed. Results: The 24 PWS patients (mean age 10.7; 6 < 8 yr old, range 4.9-18) had a preoperative BMI of 46.2 ± 12.2 kg/m2. All PWS patients had obstructive sleep apnea (OSA), 62% had dyslipidemia, 43% had hypertension, and 29% had diabetes mellitus. BMI change at the first, second, third, fourth, and fifth annual visits was -14.7 (n = 22 patients), -15.0 (n = 18), 12.2 (n = 13), -12.7 (n = 11), and -10.7 (n = 7), respectively, in the PWS group, whereas the non-PWS group had a BMI change of -15.9 (n = 67), -18.0 (n = 50), -18.4 (n = 47), -18.9 (n = 26), and -19.0 (n = 20), respectively. No significant difference was observed in postoperative BMI change (P = .2-.7) or growth (postoperative height z-score P value at each annual visit = .2-.8); 95% of co-morbidities in both groups were in remission or improved, with no significant difference in the rate of co-morbidity resolution after surgery (P = .73). One PWS patient was readmitted 5 years after surgery with recurrence of OSA and heart failure. No other readmissions occurred, and there were no reoperations, postoperative leaks, or other complications. No mortality or major morbidity was observed during the 5 years of follow-up. Among the PWS patients who reached their follow-up visit time points the total follow-up rate was 94.1%, whereas in the non-PWS group it was 97%. All patients who missed a follow-up visit were subsequently seen in future follow-ups, and no patient was lost to follow-up in either group. Conclusions: PWS children and adolescents underwent effective weight loss and resolution of comorbidities after LSG, without mortality, significant morbidity, or slowing of growth. LSG should be offered to obese PWS patients with heightened mortality particularly because no other effective alternative therapy is available.
AB - Background: Obesity is a leading cause of mortality and morbidity in Prader-Willi syndrome (PWS). Objectives: To study weight loss and growth after laparoscopic sleeve gastrectomy (LSG) in pediatric patients with PWS compared with those without the syndrome. Setting: Academic center with a standardized care pathway for pediatric bariatric surgery as a part of a prospective clinical outcome study on children and adolescents undergoing weight loss surgery. Methods: Clinical data of all PWS patients who underwent LSG were abstracted from our prospective database, which included all pediatric patients who underwent bariatric surgery. These data were then compared with a 1:3 non-PWS group matched for age, gender, and body mass index (BMI). Data for up to 5 years follow-up were analyzed. Results: The 24 PWS patients (mean age 10.7; 6 < 8 yr old, range 4.9-18) had a preoperative BMI of 46.2 ± 12.2 kg/m2. All PWS patients had obstructive sleep apnea (OSA), 62% had dyslipidemia, 43% had hypertension, and 29% had diabetes mellitus. BMI change at the first, second, third, fourth, and fifth annual visits was -14.7 (n = 22 patients), -15.0 (n = 18), 12.2 (n = 13), -12.7 (n = 11), and -10.7 (n = 7), respectively, in the PWS group, whereas the non-PWS group had a BMI change of -15.9 (n = 67), -18.0 (n = 50), -18.4 (n = 47), -18.9 (n = 26), and -19.0 (n = 20), respectively. No significant difference was observed in postoperative BMI change (P = .2-.7) or growth (postoperative height z-score P value at each annual visit = .2-.8); 95% of co-morbidities in both groups were in remission or improved, with no significant difference in the rate of co-morbidity resolution after surgery (P = .73). One PWS patient was readmitted 5 years after surgery with recurrence of OSA and heart failure. No other readmissions occurred, and there were no reoperations, postoperative leaks, or other complications. No mortality or major morbidity was observed during the 5 years of follow-up. Among the PWS patients who reached their follow-up visit time points the total follow-up rate was 94.1%, whereas in the non-PWS group it was 97%. All patients who missed a follow-up visit were subsequently seen in future follow-ups, and no patient was lost to follow-up in either group. Conclusions: PWS children and adolescents underwent effective weight loss and resolution of comorbidities after LSG, without mortality, significant morbidity, or slowing of growth. LSG should be offered to obese PWS patients with heightened mortality particularly because no other effective alternative therapy is available.
KW - Bariatric surgery
KW - Children and adolescents
KW - Prader-Willi syndrome
KW - Sleeve gastrectomy
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=84959478063&partnerID=8YFLogxK
U2 - 10.1016/j.soard.2015.07.014
DO - 10.1016/j.soard.2015.07.014
M3 - Article
C2 - 26431633
VL - 12
SP - 100
EP - 110
JO - Surgery for Obesity and Related Diseases
JF - Surgery for Obesity and Related Diseases
IS - 1
ER -