Kinetics of skin resealing after insertion of microneedles in human subjects

J. Gupta, Harvinder Gill, S. N. Andrews, M. R. Prausnitz

Research output: Contribution to journalArticlepeer-review

Abstract

Over the past decade, microneedles have been shown to dramatically increase skin permeability to a broad range of compounds by creating reversible microchannels in the skin. However, in order to achieve sustained transdermal drug delivery, the extent and duration of skin’s increased permeability needs to be determined. In this study, we used electrical impedance spectroscopy to perform the first experiments in human subjects to analyze the resealing of skin’s barrier properties after insertion of microneedles. Microneedles having a range of geometries were studied in conjunction with the effect of occlusion to test the hypothesis that increasing microneedle length, number, and cross-sectional area together with occlusion leads to an increase in skin resealing time that can exceed one day. Results indicated that in the absence of occlusion, all microneedle treated sites recovered barrier properties within 2 h, while occluded sites resealed more slowly, with resealing windows ranging fr
Original languageEnglish
Pages (from-to)148-55
JournalJ Control Release
StatePublished - 2011

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