Key Considerations for Accurate Exposures in Ecotoxicological Assessments of Perfluorinated Carboxylates and Sulfonates

Justin N. Rewerts; Emerson C. Christie; Alix E. Robel; Todd A. Anderson; Christopher McCarthy; Christopher J. Salice; Jennifer A. Field

doi:10.1002/etc.4667

Key Considerations for Accurate Exposures in Ecotoxicological Assessments of Perfluorinated Carboxylates and Sulfonates

Justin N. Rewerts, Emerson C. Christie, Alix E. Robel, Todd A. Anderson, Christopher McCarthy, Christopher J. Salice, Jennifer A. Field

Environmental Toxicology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Toxicity reference values for per- and polyfluoroalkyl substances (PFAS) vary even when the same test organism is studied. Although the need to confirm dosing solution concentrations is widely accepted, there are no experimental data to inform best practices when PFAS solutions are prepared. Laboratory data indicate that dissolution time of PFAS solids causes statistically significant deviations between nominal and measured concentrations. Mixing times for select PFAS varied between 2 and 5 h, depending on carbon fluorine chain-length. Environ Toxicol Chem 2021;40:677–688.

Original language	English
Pages (from-to)	677-688
Number of pages	12
Journal	Environmental Toxicology and Chemistry
Volume	40
Issue number	3
DOIs	https://doi.org/10.1002/etc.4667
State	Published - Mar 2021

Keywords

Dosing
Ecotoxicology
Exposure
Per- and polyfluoroalkyl substances
Variability

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10.1002/etc.4667

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title = "Key Considerations for Accurate Exposures in Ecotoxicological Assessments of Perfluorinated Carboxylates and Sulfonates",

abstract = "Toxicity reference values for per- and polyfluoroalkyl substances (PFAS) vary even when the same test organism is studied. Although the need to confirm dosing solution concentrations is widely accepted, there are no experimental data to inform best practices when PFAS solutions are prepared. Laboratory data indicate that dissolution time of PFAS solids causes statistically significant deviations between nominal and measured concentrations. Mixing times for select PFAS varied between 2 and 5 h, depending on carbon fluorine chain-length. Environ Toxicol Chem 2021;40:677–688.",

keywords = "Dosing, Ecotoxicology, Exposure, Per- and polyfluoroalkyl substances, Variability",

author = "Rewerts, {Justin N.} and Christie, {Emerson C.} and Robel, {Alix E.} and Anderson, {Todd A.} and Christopher McCarthy and Salice, {Christopher J.} and Field, {Jennifer A.}",

note = "Funding Information: The present study was supported by the Strategic Environmental Research and Development Program (grant SERDP ER‐2627). Publisher Copyright: {\textcopyright} 2020 SETAC",

year = "2021",

month = mar,

doi = "10.1002/etc.4667",

language = "English",

volume = "40",

pages = "677--688",

journal = "Environmental Toxicology and Chemistry",

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Key Considerations for Accurate Exposures in Ecotoxicological Assessments of Perfluorinated Carboxylates and Sulfonates. / Rewerts, Justin N.; Christie, Emerson C.; Robel, Alix E.; Anderson, Todd A.; McCarthy, Christopher; Salice, Christopher J.; Field, Jennifer A.

In: Environmental Toxicology and Chemistry, Vol. 40, No. 3, 03.2021, p. 677-688.

Research output: Contribution to journal › Article › peer-review

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AU - Rewerts, Justin N.

AU - Christie, Emerson C.

AU - Robel, Alix E.

AU - Anderson, Todd A.

AU - McCarthy, Christopher

AU - Salice, Christopher J.

AU - Field, Jennifer A.

PY - 2021/3

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AB - Toxicity reference values for per- and polyfluoroalkyl substances (PFAS) vary even when the same test organism is studied. Although the need to confirm dosing solution concentrations is widely accepted, there are no experimental data to inform best practices when PFAS solutions are prepared. Laboratory data indicate that dissolution time of PFAS solids causes statistically significant deviations between nominal and measured concentrations. Mixing times for select PFAS varied between 2 and 5 h, depending on carbon fluorine chain-length. Environ Toxicol Chem 2021;40:677–688.

KW - Dosing

KW - Ecotoxicology

KW - Exposure

KW - Per- and polyfluoroalkyl substances

KW - Variability

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Key Considerations for Accurate Exposures in Ecotoxicological Assessments of Perfluorinated Carboxylates and Sulfonates

Abstract

Keywords

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