The CL26 cell line was used to establish the role of AP-1 activity. The time course of c-Jun, JunB and JunD during the differentiation of C2C12 (control) and CL26 cell line myoblasts were monitored. Both the control and engineered cell lines were induced to differentiate by reducing serum concentration. Results support the hypothesis that decreased AP-1 activity is a sufficient condition for the onset of differentiation.
|Journal||Annals of Biomedical Engineering|
|Issue number||SUPPL. 1|
|State||Published - 2000|
|Event||2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA|
Duration: Oct 12 2000 → Oct 14 2000