Abstract
A new, metal-free intermolecular formal [3 + 2] heterocyclization between triethylammonium thiolates and aryl hydrazines has been established by using the combination of I2 and O2 as efficient oxidation sources, allowing a concise and low-cost access to new densely functionalized 1,2,3-thiadiazoles with good to excellent yields. The reaction showed a broad scope of substrates of both reactants and attractive characteristics consisting of eco-friendly oxidants, flexible structural modification, broad functional group compatibility, and mild reaction conditions.
Original language | English |
---|---|
Pages (from-to) | 1258-1261 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 18 |
Issue number | 6 |
DOIs | |
State | Published - Mar 18 2016 |