Abstract
A new, metal-free intermolecular formal [3 + 2] heterocyclization between triethylammonium thiolates and aryl hydrazines has been established by using the combination of I2 and O2 as efficient oxidation sources, allowing a concise and low-cost access to new densely functionalized 1,2,3-thiadiazoles with good to excellent yields. The reaction showed a broad scope of substrates of both reactants and attractive characteristics consisting of eco-friendly oxidants, flexible structural modification, broad functional group compatibility, and mild reaction conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 1258-1261 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 18 2016 |
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Fan, W., Li, Q., Li, Y., Sun, H., Jiang, B., & Li, G. (2016). I2/O2-Enabled N-S Bond Formation to Access Functionalized 1,2,3-Thiadiazoles. Organic Letters, 18(6), 1258-1261. https://doi.org/10.1021/acs.orglett.6b00079