I2-Catalyzed sulfenylation of indoles and pyrroles using triethylammonium thiolates as sulfenylating agents

Wei Fan, Zhen Yang, Bo Jiang, Guigen Li

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Readily available triethylammonium thiolates were proved to be new and eco-friendly sulfenylating agents for the efficient and practical construction of sulfenylated indoles and pyrroles (48 examples) with good to excellent yields under metal-free and microwave irradiation conditions. The combination of I2 and DMSO enabled direct C-S bond formation, allowing easy and low-cost access to new functionalized C,S-tethered bisindoles and pyrrole-indole pairs with a wide diversity of substituents. The mechanism involving S-S and S-I bond-forming/breaking events was proposed.

Original languageEnglish
Pages (from-to)1091-1102
Number of pages12
JournalOrganic Chemistry Frontiers
Volume4
Issue number6
DOIs
StatePublished - Jun 2017

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