Is hunger important to model in fMRI visual food-cue reactivity paradigms in adults with obesity and how should this be done?

Shao Hua Chin, Chanaka Kahathuduwa, Macy B Stearns, Tyler Davis, Martin Binks

Research output: Contribution to journalArticlepeer-review

Abstract

We considered 1) influence of self-reported hunger in behavioral and fMRI food-cue reactivity (fMRI-FCR) 2) optimal methods to model this. Adults (N = 32; 19–60 years; F = 21; BMI 30–39.9 kg/m2) participated in an fMRI-FCR task that required rating 240 images of food and matched objects for ‘appeal’. Hunger, satiety, thirst, fullness and emptiness were measured pre- and post-scan (visual analogue scales). Hunger, satiety, fullness and emptiness were combined to form a latent factor (appetite). Post-vs. pre-scores were compared using paired t-tests. In mixed-effects models, appeal/fMRI-FCR responses were regressed on image (i.e. food/objects), with random intercepts and slopes of image for functional runs nested within subjects. Each of hunger, satiety, thirst, fullness, emptiness and appetite were added as covariates in 4 forms (separate models): 1) change; 2) post- and pre-mean; 3) pre-; 4) change and pre-. Satiety decreased (Δ = −13.39, p = 0.001) and thirst increased (Δ = 11.78,
Original languageEnglish
Pages (from-to)388-397
JournalAppetite / Elsevier B.V.
DOIs
StatePublished - Sep 28 2017

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