TY - JOUR
T1 - Is hunger important to model in fMRI visual food-cue reactivity paradigms in adults with obesity and how should this be done?
AU - Chin, Shao Hua
AU - Kahathuduwa, Chanaka N.
AU - Stearns, Macy B.
AU - Davis, Tyler
AU - Binks, Martin
N1 - Funding Information:
This work was supported by Nestlé Health Science Inc., Florham Park, NJ . The funding agency was not involved in decisions to publish the outcomes. The authors have no other potential conflicts of interest to declare.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/1/1
Y1 - 2018/1/1
N2 - We considered 1) influence of self-reported hunger in behavioral and fMRI food-cue reactivity (fMRI-FCR) 2) optimal methods to model this. Adults (N = 32; 19–60 years; F = 21; BMI 30–39.9 kg/m2) participated in an fMRI-FCR task that required rating 240 images of food and matched objects for ‘appeal’. Hunger, satiety, thirst, fullness and emptiness were measured pre- and post-scan (visual analogue scales). Hunger, satiety, fullness and emptiness were combined to form a latent factor (appetite). Post-vs. pre-scores were compared using paired t-tests. In mixed-effects models, appeal/fMRI-FCR responses were regressed on image (i.e. food/objects), with random intercepts and slopes of image for functional runs nested within subjects. Each of hunger, satiety, thirst, fullness, emptiness and appetite were added as covariates in 4 forms (separate models): 1) change; 2) post- and pre-mean; 3) pre-; 4) change and pre-. Satiety decreased (Δ = −13.39, p = 0.001) and thirst increased (Δ = 11.78, p = 0.006) during the scan. Changes in other constructs were not significant (p's > 0.05). Including covariates did not influence food vs. object contrast of appeal ratings/fMRI-FCR. Significant image X covariate interactions were observed in some fMRI models. However, including these constructs did not improve the overall model fit. While some subjective, self-reported hunger, satiety and related constructs may be moderating fMRI-FCR, these constructs do not appear to be salient influences on appeal/fMRI-FCR in people with obesity undergoing fMRI.
AB - We considered 1) influence of self-reported hunger in behavioral and fMRI food-cue reactivity (fMRI-FCR) 2) optimal methods to model this. Adults (N = 32; 19–60 years; F = 21; BMI 30–39.9 kg/m2) participated in an fMRI-FCR task that required rating 240 images of food and matched objects for ‘appeal’. Hunger, satiety, thirst, fullness and emptiness were measured pre- and post-scan (visual analogue scales). Hunger, satiety, fullness and emptiness were combined to form a latent factor (appetite). Post-vs. pre-scores were compared using paired t-tests. In mixed-effects models, appeal/fMRI-FCR responses were regressed on image (i.e. food/objects), with random intercepts and slopes of image for functional runs nested within subjects. Each of hunger, satiety, thirst, fullness, emptiness and appetite were added as covariates in 4 forms (separate models): 1) change; 2) post- and pre-mean; 3) pre-; 4) change and pre-. Satiety decreased (Δ = −13.39, p = 0.001) and thirst increased (Δ = 11.78, p = 0.006) during the scan. Changes in other constructs were not significant (p's > 0.05). Including covariates did not influence food vs. object contrast of appeal ratings/fMRI-FCR. Significant image X covariate interactions were observed in some fMRI models. However, including these constructs did not improve the overall model fit. While some subjective, self-reported hunger, satiety and related constructs may be moderating fMRI-FCR, these constructs do not appear to be salient influences on appeal/fMRI-FCR in people with obesity undergoing fMRI.
KW - Food-cue reactivity
KW - Hunger
KW - Neuroimaging
KW - Obesity
KW - Satiety
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=85030669382&partnerID=8YFLogxK
U2 - 10.1016/j.appet.2017.09.012
DO - 10.1016/j.appet.2017.09.012
M3 - Article
C2 - 28964904
AN - SCOPUS:85030669382
VL - 120
SP - 388
EP - 397
JO - Appetite
JF - Appetite
SN - 0195-6663
ER -