Iron-catalyzed alkenylation of cyclic ethers via decarboxylative sp 3(C)-sp2(C) coupling

Jincan Zhao, Wei Zhou, Jianlin Han, Guigen Li, Yi Pan

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

An efficient Fe(acac)3-catalyzed decarboxylative C(sp 2)-C(sp3) coupling reaction via oxidation of C-H bond adjacent to an oxygen atom has been developed successfully, in which cyclic ethers are selectively transformed into the corresponding alkenylation products with good chemical yields and excellent stereoselectivities. The mechanism was studied and the reaction was supposed to proceed through a radical oxidative coupling process.

Original languageEnglish
Pages (from-to)6507-6510
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number48
DOIs
StatePublished - Nov 27 2013

Keywords

  • Alkenylation
  • Coupling
  • Decarboxylative
  • Fe(acac)
  • Oxidation

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