Abstract
A practical iridium-catalyzed cascade/stepwise synthesis of dihydroquinazolinones (DHQs) and bis-DHQs fused to medium to large N-heterocyclic rings is developed. The reaction undergoes benzamide-directed intermolecular C-H amination with an aldehyde-tethered alkyl azide, and then the newly installed amino group undergoes intramolecular cyclization with a remote aldehyde group present in azide and amidyl group of benzamide either intrinsically or catalyzed by phosphoric acid, facilitating the formation of bicyclic and/or tricyclic rings in a very efficient manner.
Original language | English |
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Pages (from-to) | 3706-3710 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 21 |
Issue number | 10 |
DOIs | |
State | Published - May 17 2019 |