Iridium-Catalyzed Aryl C-H Sulfonamidation and Amide Formation Using a Bifunctional Nitrogen Source

Meng Yu, Tao Zhang, Hitesh B. Jalani, Xunqing Dong, Hongjian Lu, Guigen Li

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A new strategy for the sequential formation of aryl and amidyl C-N bonds is reported. Using trichloroethoxysulfonyl azide as a bifunctional nitrogen source, Ir-catalyzed aryl C-H sulfonamidation and subsequent desulfonative amide formation proceed effectively without any need of oxidants or coupling reagents. This protocol is suitable for readily available benzamides and stable carboxylates including primary, secondary, and tertiary alkyl, alkenyl, and phenyl carboxylates, thereby providing a direct and efficient method for the synthesis of biologically and chemically useful N-arylamides.

Original languageEnglish
Pages (from-to)4828-4832
Number of pages5
JournalOrganic Letters
Volume20
Issue number16
DOIs
StatePublished - Aug 17 2018

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