The intermolecular direct C-H alkylation of aniline derivatives with alpha-bromo ketones to build a quaternary carbon center was reported with a visible-light catalysis procedure. The reaction covers a variety of functional groups with good to excellent yields. A regioselectivity favoring the ortho position for the amine group was observed and investigated with Fukui indices and spectral methods.
|State||Published - Sep 2016|
Cheng, J., Deng, X., Wang, G., Li, Y., Cheng, X., & Li, G. (2016). Intermolecular C-H Quaternary Alkylation of Aniline Derivatives Induced by Visible-Light Photoredox Catalysis. Organic Letters, 4538-4541.