Intermolecular C-H Quaternary Alkylation of Aniline Derivatives Induced by Visible-Light Photoredox Catalysis

Jie Cheng, Xia Deng, Guoqiang Wang, Ying Li, Xu Cheng, Guigen Li

Research output: Contribution to journalArticle

Abstract

The intermolecular direct C-H alkylation of aniline derivatives with alpha-bromo ketones to build a quaternary carbon center was reported with a visible-light catalysis procedure. The reaction covers a variety of functional groups with good to excellent yields. A regioselectivity favoring the ortho position for the amine group was observed and investigated with Fukui indices and spectral methods.
Original languageEnglish
Pages (from-to)4538-4541
JournalOrganic Letters
StatePublished - Sep 2016

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