Integrative design, build, test approach for biomedical devices with lattice structures

Paul F. Egan, Isabella Bauer, Kristina Shea, Stephen J. Ferguson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Advances in 3D printing are enabling new rapid prototyping strategies for complex structures, such as mechanically efficient tissue scaffolds. Here, we have developed an integrated methodology with Design, Build, and Test phases to characterize beam-based lattices for bone tissue engineering. Lattices were designed with 50% and 70% porosity with beam diameters of 0.4mm to 1.0mm fabricated with polyjet printing. Build accuracy was validated with microscopy that demonstrated overall lattice dimensions were at most 0.2mm different from design and beam diameters were at most 0.15mm different. Quasi-static compression testing showed lattice elastic moduli ranged from 28MPa to 180MPa and decreased with higher lattice porosity but increased with larger beam diameter sizes. Scaffold cages for vertebral bone fusion were prototyped using 50% and 70% porous lattices with 0.8mm diameter beams with added central voids for improved nutrient transport, reinforced shells for increased mechanics, or both. Cage stiffnesses ranged from 1.7kN/mm to 7.2kN/mm and suggests the strongest cage prototypes are suitable for carrying typical spinal loads of up to 1.65kN. The study demonstrates the value in using integrated rapid prototyping approaches for characterizing complex structures and designing novel biomedical devices.

Original languageEnglish
Title of host publication30th International Conference on Design Theory and Methodology
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791851845
DOIs
StatePublished - 2018
EventASME 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2018 - Quebec City, Canada
Duration: Aug 26 2018Aug 29 2018

Publication series

NameProceedings of the ASME Design Engineering Technical Conference
Volume7

Conference

ConferenceASME 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2018
CountryCanada
CityQuebec City
Period08/26/1808/29/18

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  • Cite this

    Egan, P. F., Bauer, I., Shea, K., & Ferguson, S. J. (2018). Integrative design, build, test approach for biomedical devices with lattice structures. In 30th International Conference on Design Theory and Methodology (Proceedings of the ASME Design Engineering Technical Conference; Vol. 7). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DETC2018-85355