Integrated peptide and glycan biomarker discovery using MALDI-TOF mass spectrometry

Rency S. Varghese, Lenka Goldman, Yanming An, Christopher A. Loffredo, Mohamed Abdel-Hamid, Zuzana Kyselova, Yehia Mechref, Milos Novotny, Steve K. Drake, Radoslav Goldman, Habtom W. Ressom

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Quantitative comparison of peptides and glycans in serum is conducted using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) to identify biomarkers. A peak selection algorithm is developed to identify a panel of integrated peptide and glycan peaks to distinguish hepatocellular carcinoma (HCC) cases from high-risk population of patients with chronic liver disease (CLD). Candidate peptide and glycan markers selected frequently in multiple runs of the algorithm are presented. The performance of these markers is evaluated in terms of their ability to distinguish HCC cases from patients with CLD in a blinded validation set.

Original languageEnglish
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
PublisherIEEE Computer Society
Pages3791-3794
Number of pages4
ISBN (Print)9781424418152
DOIs
StatePublished - 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Publication series

NameProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Conference

Conference30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period08/20/0808/25/08

Fingerprint Dive into the research topics of 'Integrated peptide and glycan biomarker discovery using MALDI-TOF mass spectrometry'. Together they form a unique fingerprint.

  • Cite this

    Varghese, R. S., Goldman, L., An, Y., Loffredo, C. A., Abdel-Hamid, M., Kyselova, Z., Mechref, Y., Novotny, M., Drake, S. K., Goldman, R., & Ressom, H. W. (2008). Integrated peptide and glycan biomarker discovery using MALDI-TOF mass spectrometry. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 (pp. 3791-3794). [4650034] (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"). IEEE Computer Society. https://doi.org/10.1109/iembs.2008.4650034