Influence of plasma lipid changes in response to 17β-oestradiol stimulation on plasma growth hormone, somatostatin, and thyroid hormone levels in immature rainbow trout

F. Mercure, A. C. Holloway, D. R. Tocher, M. A. Sheridan, G. Van Der Kraak, J. F. Leatherland

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27 Scopus citations

Abstract

Plasma total lipids were significantly higher in 17β-oestradiol (E2)-treated immature rainbow trout Oncorhynchus mykiss at week 4 after implantation, due to increases in polar and neutral lipids. The lipid classes responding were phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, sterols and sterol esters, in a proportion that approximately reflected the increase in plasma vitellogenin (VtG) levels as measured by a non-competitive enzyme-linked immunosorbent assay (ELISA). Plasma non-esterified fatty acids and triacylglycerol were not affected by E2 treatment. Plasma growth hormone GH levels were increased, and plasma somatostatin-14 (SRIF) levels decreased in E2-treated fish, responses which could be secondary to elevated plasma lipid (VtG) content, although a direct E2 action on somatotroph function is possible. Plasma T4 concentrations were not affected by E2 treatment, but plasma T3 concentrations were significantly lower than in controls 1 week after implantation when plasma E2 concentrations were the highest; this is in support of the hypothesis that E2 has a suppressive action on T3 production.

Original languageEnglish
Pages (from-to)605-615
Number of pages11
JournalJournal of Fish Biology
Volume59
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Neutral lipid
  • Oestrogen
  • Phospholipid
  • Polar lipid
  • Reproduction
  • Vitellogenin

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