Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women

Arturo Figueroa, Stacey Alvarez-Alvarado, Salvador J. Jaime, Sarah A. Johnson, Jeremiah C. Campbell, Rafaela G. Feresin, Marcus L. Elam, Negin Navaei, Shirin Pourafshar, Bahram H. Arjmandi

Research output: Contribution to journalLetter

2 Scopus citations

Abstract

Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.

Original languageEnglish
Pages (from-to)1243-1246
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume43
Issue number12
DOIs
StatePublished - Dec 1 2016

Keywords

  • aging
  • aortic haemodynamic responses
  • appendicular skeletal muscle mass
  • arterial stiffness
  • isometric exercise
  • obesity

Fingerprint Dive into the research topics of 'Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women'. Together they form a unique fingerprint.

  • Cite this