TY - JOUR
T1 - Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women
AU - Figueroa, Arturo
AU - Alvarez-Alvarado, Stacey
AU - Jaime, Salvador J.
AU - Johnson, Sarah A.
AU - Campbell, Jeremiah C.
AU - Feresin, Rafaela G.
AU - Elam, Marcus L.
AU - Navaei, Negin
AU - Pourafshar, Shirin
AU - Arjmandi, Bahram H.
N1 - Publisher Copyright:
© 2016 John Wiley & Sons Australia, Ltd
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.
AB - Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.
KW - aging
KW - aortic haemodynamic responses
KW - appendicular skeletal muscle mass
KW - arterial stiffness
KW - isometric exercise
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=84996490666&partnerID=8YFLogxK
U2 - 10.1111/1440-1681.12655
DO - 10.1111/1440-1681.12655
M3 - Letter
C2 - 27558210
AN - SCOPUS:84996490666
VL - 43
SP - 1243
EP - 1246
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
SN - 0305-1870
IS - 12
ER -