Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women

Arturo Figueroa; Stacey Alvarez-Alvarado; Salvador J. Jaime; Sarah A. Johnson; Jeremiah C. Campbell; Rafaela G. Feresin; Marcus L. Elam; Negin Navaei; Shirin Pourafshar; Bahram H. Arjmandi

doi:10.1111/1440-1681.12655

Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women

Arturo Figueroa, Stacey Alvarez-Alvarado, Salvador J. Jaime, Sarah A. Johnson, Jeremiah C. Campbell, Rafaela G. Feresin, Marcus L. Elam, Negin Navaei, Shirin Pourafshar, Bahram H. Arjmandi

Kinesiology and Sport Management

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Abstract

Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height² (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.

Original language	English
Pages (from-to)	1243-1246
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	43
Issue number	12
DOIs	https://doi.org/10.1111/1440-1681.12655
State	Published - Dec 1 2016

Keywords

aging
aortic haemodynamic responses
appendicular skeletal muscle mass
arterial stiffness
isometric exercise
obesity

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10.1111/1440-1681.12655

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Figueroa, A., Alvarez-Alvarado, S., Jaime, S. J., Johnson, S. A., Campbell, J. C., Feresin, R. G., Elam, M. L., Navaei, N., Pourafshar, S., & Arjmandi, B. H. (2016). Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women. Clinical and Experimental Pharmacology and Physiology, 43(12), 1243-1246. https://doi.org/10.1111/1440-1681.12655

Figueroa, Arturo ; Alvarez-Alvarado, Stacey ; Jaime, Salvador J. ; Johnson, Sarah A. ; Campbell, Jeremiah C. ; Feresin, Rafaela G. ; Elam, Marcus L. ; Navaei, Negin ; Pourafshar, Shirin ; Arjmandi, Bahram H. / Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women. In: Clinical and Experimental Pharmacology and Physiology. 2016 ; Vol. 43, No. 12. pp. 1243-1246.

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title = "Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women",

abstract = "Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.",

keywords = "aging, aortic haemodynamic responses, appendicular skeletal muscle mass, arterial stiffness, isometric exercise, obesity",

author = "Arturo Figueroa and Stacey Alvarez-Alvarado and Jaime, {Salvador J.} and Johnson, {Sarah A.} and Campbell, {Jeremiah C.} and Feresin, {Rafaela G.} and Elam, {Marcus L.} and Negin Navaei and Shirin Pourafshar and Arjmandi, {Bahram H.}",

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doi = "10.1111/1440-1681.12655",

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Figueroa, A, Alvarez-Alvarado, S, Jaime, SJ, Johnson, SA, Campbell, JC, Feresin, RG, Elam, ML, Navaei, N, Pourafshar, S & Arjmandi, BH 2016, 'Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women', Clinical and Experimental Pharmacology and Physiology, vol. 43, no. 12, pp. 1243-1246. https://doi.org/10.1111/1440-1681.12655

Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women. / Figueroa, Arturo; Alvarez-Alvarado, Stacey; Jaime, Salvador J.; Johnson, Sarah A.; Campbell, Jeremiah C.; Feresin, Rafaela G.; Elam, Marcus L.; Navaei, Negin; Pourafshar, Shirin; Arjmandi, Bahram H.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 43, No. 12, 01.12.2016, p. 1243-1246.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women

AU - Figueroa, Arturo

AU - Alvarez-Alvarado, Stacey

AU - Jaime, Salvador J.

AU - Johnson, Sarah A.

AU - Campbell, Jeremiah C.

AU - Feresin, Rafaela G.

AU - Elam, Marcus L.

AU - Navaei, Negin

AU - Pourafshar, Shirin

AU - Arjmandi, Bahram H.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.

AB - Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.

KW - aging

KW - aortic haemodynamic responses

KW - appendicular skeletal muscle mass

KW - arterial stiffness

KW - isometric exercise

KW - obesity

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U2 - 10.1111/1440-1681.12655

DO - 10.1111/1440-1681.12655

M3 - Letter

C2 - 27558210

AN - SCOPUS:84996490666

VL - 43

SP - 1243

EP - 1246

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

SN - 0305-1870

IS - 12

ER -

Figueroa A, Alvarez-Alvarado S, Jaime SJ, Johnson SA, Campbell JC, Feresin RG et al. Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women. Clinical and Experimental Pharmacology and Physiology. 2016 Dec 1;43(12):1243-1246. https://doi.org/10.1111/1440-1681.12655

Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women

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