TY - JOUR
T1 - Influence of a thermogenic dietary supplement on safety markers, body composition, energy expenditure, muscular performance and hormone concentrations
T2 - A randomized, placebo-controlled, double-blind trial
AU - Tinsley, Grant M.
AU - Urbina, Stacie
AU - Mullins, Jacy
AU - Outlaw, Jordan
AU - Hayward, Sara
AU - Stone, Matt
AU - Foster, Cliffa
AU - Wilborn, Colin
AU - Taylor, Lem
N1 - Funding Information:
The study was designed by LT, JM, and JO; data were collected and analyzed by SU, JM, JO, SH, and MS; data interpretation and manuscript preparation were undertaken by GMT, CF, CW, and LT. All authors approved the final version of the paper. This study was supported by a research grant awarded by the International Society of Sports Nutrition to the investigators in the Human Performance Lab at the University of Mary Hardin-Baylor. This research grant was sponsored by MusclePharm Corporation. The sponsoring organization was not involved in the study design, data collection or data analysis. No authors declare conflicts of interest. The reported experiments comply with the current laws of the country in which they were performed.
Publisher Copyright:
©Journal of Sports Science and Medicine.
PY - 2017/12
Y1 - 2017/12
N2 - Dietary supplementation is commonly employed by individuals seeking to improve body composition and exercise performance. The purpose of the present study was to examine the safety and effectiveness of a commercially available dietary supplement designed to promote thermogenesis and fat loss. In a randomized double-blind trial, participants were assigned to consume placebo or a multi-ingredient supplement containing caffeine, green tea extract, l-carnitine, evodiamine and other ingredients that purportedly enhance thermogenesis. The study included acute baseline testing, a 6-week progressive resistance training and supplementation intervention, and post-intervention testing. Laboratory assessments included resting energy expenditure responses to acute supplement ingestion, evaluation of body composition and muscular performance, and analysis of blood variables (metabolic panel, testosterone, estrogen and cortisol). Dependent variables were analyzed using ANOVA with repeated measures. No unfavorable effects of supplementation were reported, and the supplement did not adversely affect safety markers. However, the supplement did not reduce fat mass or increase lean mass relative to placebo. In the supplement group, lower body maximal strength was increased relative to placebo (+18%, d=1.1 vs. +10%, d=0.5), and cortisol concentrations were decreased relative to placebo (-16%; d=-0.4 vs. +15%, d=.75). However, no differences were observed for upper body maximal strength or muscular endurance. REE increased in response to both supplement and placebo ingestion (placebo: +5%; supplement: +11.5%), but the difference between conditions was not statistically significant. Overall, some select parameters may have been beneficially modified by supplementation, but this did not result in superior weight or fat loss over 6 weeks of supplementation and resistance training.
AB - Dietary supplementation is commonly employed by individuals seeking to improve body composition and exercise performance. The purpose of the present study was to examine the safety and effectiveness of a commercially available dietary supplement designed to promote thermogenesis and fat loss. In a randomized double-blind trial, participants were assigned to consume placebo or a multi-ingredient supplement containing caffeine, green tea extract, l-carnitine, evodiamine and other ingredients that purportedly enhance thermogenesis. The study included acute baseline testing, a 6-week progressive resistance training and supplementation intervention, and post-intervention testing. Laboratory assessments included resting energy expenditure responses to acute supplement ingestion, evaluation of body composition and muscular performance, and analysis of blood variables (metabolic panel, testosterone, estrogen and cortisol). Dependent variables were analyzed using ANOVA with repeated measures. No unfavorable effects of supplementation were reported, and the supplement did not adversely affect safety markers. However, the supplement did not reduce fat mass or increase lean mass relative to placebo. In the supplement group, lower body maximal strength was increased relative to placebo (+18%, d=1.1 vs. +10%, d=0.5), and cortisol concentrations were decreased relative to placebo (-16%; d=-0.4 vs. +15%, d=.75). However, no differences were observed for upper body maximal strength or muscular endurance. REE increased in response to both supplement and placebo ingestion (placebo: +5%; supplement: +11.5%), but the difference between conditions was not statistically significant. Overall, some select parameters may have been beneficially modified by supplementation, but this did not result in superior weight or fat loss over 6 weeks of supplementation and resistance training.
KW - Adipose tissue
KW - Metabolism
KW - Resistance training
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=85035145957&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85035145957
VL - 16
SP - 459
EP - 467
JO - Journal of Sports Science and Medicine
JF - Journal of Sports Science and Medicine
SN - 1303-2968
IS - 4
ER -