In vitro dynamic strain analysis on porcine mitral valve

Z. M. He, L. Baijens, S. Wanant, P. Shah, S. He, B. Sugimoto, M. S. Sacks, A. P. Yoganathan

Research output: Contribution to journalConference article

Abstract

Dual camera stereo photogrammetry was used to quantify the deformation of the central region of the anterior leaflet of the mitral valve operating in a flow loop under the physiological and pathological condition. Stretches and strains were measured and analyzed. The principal stretches demonstrated a rapid rise early in leaflet closure, followed by a plateau, suggesting that the collagen fibers "locked" in place. There is a big difference between the major principal stretch and minor principal stretch. Similar to in-vitro tissue mechanics studies, the transmitral pressure-areal strain relationship during loading and unloading clearly demonstrated hysteresis. Further, this relationship demonstrated a dramatic stiffening attributed to collagen fiber locking. When the data of 3 papillary muscle positions were compared, the leaflet in the slack papillary position showed the highest areal strain rate. The valve exhibited a strongly anisotropic behavior. Papillary muscle position had a small effect on strain measured in the region.

Keywords

  • Collagen orientation distribution
  • Marker technique
  • Porcine mitral valve
  • Strain measurement

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    He, Z. M., Baijens, L., Wanant, S., Shah, P., He, S., Sugimoto, B., Sacks, M. S., & Yoganathan, A. P. (2002). In vitro dynamic strain analysis on porcine mitral valve. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, 1244-1245.