In vitro bioassessment of trophic transfer and comparisons with field monitoring of residues and effects of DDTs in sediments and male hornyhead turbot (Pleuronichthys verticalis) of Palos Verdes, CA (USA)

Jordan Crago; Elvis Xu; Allison Kupsco; Fang Jia; Alvine Mehinto; Keith Maruya; Jay Gan; Dan Schlenk

In vitro bioassessment of trophic transfer and comparisons with field monitoring of residues and effects of DDTs in sediments and male hornyhead turbot (Pleuronichthys verticalis) of Palos Verdes, CA (USA)

Jordan Crago, Elvis Xu, Allison Kupsco, Fang Jia, Alvine Mehinto, Keith Maruya, Jay Gan, Dan Schlenk

Environmental Toxicology

Research output: Contribution to journal › Article › peer-review

Abstract

High concentrations of DDT and metabolites (ΣDDT) have been detected in sediment and the demersal flatfish hornyhead turbot (Pleuronichtys verticalis) collected from Palos Verdes (PV), California, USA, a site contaminated with over 100 metric tons of DDT throughout 1960s–70s. This study was conducted to assess the transfer of ΣDDT from PV-sediment into polychaetes (Neanthes arenaceodentata) and hornyhead turbot, and to investigate if the responses in turbots from two different laboratory exposures mimic those in turbots caught in PV (PV-turbot). Turbot fed PV-sediment-contaminated polychaete for 7 days had liver concentrations of ΣDDT similar to PV-turbot. After 28 days, ΣDDT also accumulated in livers of turbot gavaged with a ΣDDT mixture. In vitro cell bioassays indicated significant increases of 17β-estradiol equivalents (EEQ) in turbot bile extracts as compared to the control in the 7-day study. These responses corresponded to those measured in PV-fish. Glucocorticoid receptor (GR

Original language	English
Pages (from-to)	940-948
Journal	Environmental Pollution
State	Published - Jun 2016

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@article{38feb2df11134fe6863195450465733e,

title = "In vitro bioassessment of trophic transfer and comparisons with field monitoring of residues and effects of DDTs in sediments and male hornyhead turbot (Pleuronichthys verticalis) of Palos Verdes, CA (USA)",

abstract = "High concentrations of DDT and metabolites (ΣDDT) have been detected in sediment and the demersal flatfish hornyhead turbot (Pleuronichtys verticalis) collected from Palos Verdes (PV), California, USA, a site contaminated with over 100 metric tons of DDT throughout 1960s–70s. This study was conducted to assess the transfer of ΣDDT from PV-sediment into polychaetes (Neanthes arenaceodentata) and hornyhead turbot, and to investigate if the responses in turbots from two different laboratory exposures mimic those in turbots caught in PV (PV-turbot). Turbot fed PV-sediment-contaminated polychaete for 7 days had liver concentrations of ΣDDT similar to PV-turbot. After 28 days, ΣDDT also accumulated in livers of turbot gavaged with a ΣDDT mixture. In vitro cell bioassays indicated significant increases of 17β-estradiol equivalents (EEQ) in turbot bile extracts as compared to the control in the 7-day study. These responses corresponded to those measured in PV-fish. Glucocorticoid receptor (GR",

author = "Jordan Crago and Elvis Xu and Allison Kupsco and Fang Jia and Alvine Mehinto and Keith Maruya and Jay Gan and Dan Schlenk",

year = "2016",

month = jun,

language = "English",

pages = "940--948",

journal = "Environmental Pollution",

publisher = "Elsevier",

}

In vitro bioassessment of trophic transfer and comparisons with field monitoring of residues and effects of DDTs in sediments and male hornyhead turbot (Pleuronichthys verticalis) of Palos Verdes, CA (USA). / Crago, Jordan; Xu, Elvis; Kupsco, Allison et al.
In: Environmental Pollution, 06.2016, p. 940-948.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - In vitro bioassessment of trophic transfer and comparisons with field monitoring of residues and effects of DDTs in sediments and male hornyhead turbot (Pleuronichthys verticalis) of Palos Verdes, CA (USA)

AU - Crago, Jordan

AU - Xu, Elvis

AU - Kupsco, Allison

AU - Jia, Fang

AU - Mehinto, Alvine

AU - Maruya, Keith

AU - Gan, Jay

AU - Schlenk, Dan

PY - 2016/6

Y1 - 2016/6

N2 - High concentrations of DDT and metabolites (ΣDDT) have been detected in sediment and the demersal flatfish hornyhead turbot (Pleuronichtys verticalis) collected from Palos Verdes (PV), California, USA, a site contaminated with over 100 metric tons of DDT throughout 1960s–70s. This study was conducted to assess the transfer of ΣDDT from PV-sediment into polychaetes (Neanthes arenaceodentata) and hornyhead turbot, and to investigate if the responses in turbots from two different laboratory exposures mimic those in turbots caught in PV (PV-turbot). Turbot fed PV-sediment-contaminated polychaete for 7 days had liver concentrations of ΣDDT similar to PV-turbot. After 28 days, ΣDDT also accumulated in livers of turbot gavaged with a ΣDDT mixture. In vitro cell bioassays indicated significant increases of 17β-estradiol equivalents (EEQ) in turbot bile extracts as compared to the control in the 7-day study. These responses corresponded to those measured in PV-fish. Glucocorticoid receptor (GR

AB - High concentrations of DDT and metabolites (ΣDDT) have been detected in sediment and the demersal flatfish hornyhead turbot (Pleuronichtys verticalis) collected from Palos Verdes (PV), California, USA, a site contaminated with over 100 metric tons of DDT throughout 1960s–70s. This study was conducted to assess the transfer of ΣDDT from PV-sediment into polychaetes (Neanthes arenaceodentata) and hornyhead turbot, and to investigate if the responses in turbots from two different laboratory exposures mimic those in turbots caught in PV (PV-turbot). Turbot fed PV-sediment-contaminated polychaete for 7 days had liver concentrations of ΣDDT similar to PV-turbot. After 28 days, ΣDDT also accumulated in livers of turbot gavaged with a ΣDDT mixture. In vitro cell bioassays indicated significant increases of 17β-estradiol equivalents (EEQ) in turbot bile extracts as compared to the control in the 7-day study. These responses corresponded to those measured in PV-fish. Glucocorticoid receptor (GR

M3 - Article

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EP - 948

JO - Environmental Pollution

JF - Environmental Pollution

ER -