In utero and lactational exposure to ammonium perchlorate in drinking water: effects on developing deer mice at postnatal day 21

Kerry A. Thuett, Ellen H. Roots, L. P. Mitchell, Angella Gentles, Todd Anderson, Ernest Smith

Research output: Contribution to journalArticle

Abstract

The effects of in utero and lactational exposure to ammonium perchlorate (AP), a component of rocket fuel and a thyroid toxicant, on developing deer mice (Peromyscus maniculatus) were evaluated. Breeding pairs were dosed continuously with 0, 1 nM, 1 micro M, or 1 mM AP in drinking water, from cohabitation until pups were euthanized at postnatal day (PND) 21. Pups from the second litter were used for evaluation in this study. No significant differences were observed in any analysis performed when litter means were used in statistical analysis. All reported significant differences occurred when statistical analysis was performed on individual pup data. Body weights were significantly different between treatments at PND 5 and PND 20, with the 1- micro M body weights being lower than that of controls. Body weight and liver weight in the 1-mM group were significantly higher than the 1- micro M weights at PND 21 when analyzed by analysis of variance (ANOVA). However, there were no significa
Original languageEnglish
Pages (from-to)1061-76
JournalJ Toxicol Environ Health A
StatePublished - Aug 9 2002

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