TY - JOUR
T1 - Improvement of the synthetic tri-peptide vaccine (S3Pvac) against porcine Taenia solium cysticercosis in search of a more effective, inexpensive and manageable vaccine
AU - Sciutto, Edda
AU - Rosas, Gabriela
AU - Hernández, Marisela
AU - Morales, Julio
AU - Cruz-Revilla, Carmen
AU - Toledo, Andrea
AU - Manoutcharian, Karen
AU - Gevorkian, Goar
AU - Blancas, Abel
AU - Acero, Gonzalo
AU - Hernández, Beatriz
AU - Cervantes, Jacquelynne
AU - Bobes, Raul J.
AU - Goldbaum, Fernando A.
AU - Huerta, Mirna
AU - Diaz-Orea, Alicia
AU - Fleury, Agnes
AU - de Aluja, Aline S.
AU - Cabrera-Ponce, Jose Luis
AU - Herrera-Estrella, Luis
AU - Fragoso, Gladis
AU - Larralde, Carlos
N1 - Funding Information:
The authors thank Gerardo Arrellín, Georgina Díaz Herrera and Mercedes Baca for technical support and Isabel Perez Montfort for English edition. This investigation was partially supported by the International Center for Genetic Engineering and Biotechnology, the Howard Hughes Medical Institute (55004134), CONACyT 2004-01-040, 46953-M, PROMEP-UAEMOR-PTC-87 (103.5/03/2530) and Dirección General de Personal Académico, Universidad Nacional Autónoma de Mexico (IN-221905).
PY - 2007/2/9
Y1 - 2007/2/9
N2 - Vaccination of pigs may curtail Taenia solium transmission by reducing the number of cysticerci, the precursors of adult intestinal tapeworms in humans. Several antigen preparations induce protection against porcine cysticercosis in experimental settings but only one subunit vaccine (S3Pvac) has been tested and proved effective in the field against naturally acquired disease. Besides improving of the vaccine's effectiveness, significant reductions in production costs and in the logistics of its administration are necessary for the feasibility of nationwide control programs. This review highlights the development of several versions of S3Pvac aimed to increase effectiveness, reduce costs and increase feasibility by novel delivery systems and alternative routes of administration.
AB - Vaccination of pigs may curtail Taenia solium transmission by reducing the number of cysticerci, the precursors of adult intestinal tapeworms in humans. Several antigen preparations induce protection against porcine cysticercosis in experimental settings but only one subunit vaccine (S3Pvac) has been tested and proved effective in the field against naturally acquired disease. Besides improving of the vaccine's effectiveness, significant reductions in production costs and in the logistics of its administration are necessary for the feasibility of nationwide control programs. This review highlights the development of several versions of S3Pvac aimed to increase effectiveness, reduce costs and increase feasibility by novel delivery systems and alternative routes of administration.
KW - Control
KW - Cysticercosis
KW - S3Pvac improvement
KW - Taenia solium
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=33846191121&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2006.10.018
DO - 10.1016/j.vaccine.2006.10.018
M3 - Review article
C2 - 17188784
AN - SCOPUS:33846191121
SN - 0264-410X
VL - 25
SP - 1368
EP - 1378
JO - Vaccine
JF - Vaccine
IS - 8
ER -