Improved Synthesis of N-Methylcadaverine

Kayla Anderson, Shiva Moaven, Daniel K. Unruh, Anthony Cozzolino, John D'Auria

Research output: Contribution to journalArticlepeer-review


Alkaloids compose a large class of natural products, and mono-methylated polyamines are a common intermediate in their biosynthesis. In order to evaluate the role of selectively methylated natural products, synthetic strategies are needed to prepare them. Here, N-methylcadaverine is prepared in 37.3\% yield in three steps. The alternative literature two-step strategy resulted in reductive deamination to give N-methylpiperidine as determined by the single crystal structure. A straightforward strategy to obtain the mono-alkylated aliphatic diamine, cadaverine, which avoids potential side-reactions, is demonstrated.
Original languageEnglish
Pages (from-to)1216
JournalDefault journal
StatePublished - May 2018


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