Improved energy model for membrane electroporation in biological cells subjected to electrical pulses

R. P. Joshi, Q. Hu, K. H. Schoenbach, H. P. Hjalmarson

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55 Scopus citations

Abstract

A self-consistent model analysis of electroporation in biological cells has been carried out based on an improved energy model. The simple energy model used in the literature is somewhat incorrect and unphysical for a variety of reasons. Our model for the pore formation energy E(r) includes a dependence on pore population and density. It also allows for variable surface tension, incorporates the effects of finite conductivity on the electrostatic correction term, and is dynamic in nature. Self-consistent calculations, based on a coupled scheme involving the Smoluchowski equation and the improved energy model, are presented. It is shown that E(r) becomes self-adjusting with variations in its magnitude and profile, in response to pore population, and inhibits uncontrolled pore growth and expansion. This theory can be augmented to include pore-pore interactions to move beyond the independent pore picture.

Original languageEnglish
Article number041920
Pages (from-to)041920/1-041920/8
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume65
Issue number4
DOIs
StatePublished - Apr 2002

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