Impaired postexercise cardiovascular autonomic modulation in middle-aged women with type 2 diabetes

Arturo Figueroa, Tracy Baynard, bo Fernhall, Robert Carhart, Jill A. Kanaley

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Type 2 diabetes is associated with cardiovascular autonomic dysfunction. Postexercise autonomic modulation may be different in obese individuals with and without type 2 diabetes. We examined postexercise responses in nondiabetic and diabetic women aged 40–60 years. Hemodynamics, high-frequency and low-frequency of RR interval, low-frequency of systolic blood pressure variability and baroreflex sensitivity were evaluated before and after a 20 min walk at ~65% of VO2 peak in eight lean, 12 obese without type 2 diabetes and eight women with type 2 diabetes. Postexercise measurements were obtained at 10–15, 20–25 and 30–35 min. Systolic blood pressure decreased at 10 (P<0.001) and 20 min (P<0.01) in all groups. Total peripheral resistance decreased at 10 min in all women, but the subsequent increase at 20 min was greater (P<0.01) in lean than in diabetic women. Log-transformed low-frequency of systolic blood pressure increased (P<0.01) at 10 and 20 min in all women, but the increase at 10 min was smaller (P<0.05) in diabetic than in lean women. Heart rate was increased (P<0.001) at 10 min in all women and at 20 min in both obese groups. Both log-transformed high-frequency of RR interval and baroreflex sensitivity decreased at 10 and 20 min of recovery in all groups. A group-by-time interaction (P<0.05) was observed for heart rate and baroreflex sensitivity as a lower heart rate and higher baroreflex sensitivity were observed in lean women than in women with type 2 diabetes. Reduced postexercise baroreflex sensitivity and responses to autonomic cardiovascular activity contribute to an attenuated recovery of heart rate and total peripheral resistance after brisk walking in middle-aged obese women with type 2 diabetes.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalEuropean Journal of Preventive Cardiology
Volume14
Issue number2
DOIs
StatePublished - Apr 2007

Keywords

  • autonomic nervous system
  • baroreflex sensitivity
  • heart rate variability
  • obesity
  • postexercise recovery
  • type 2 diabetes

Fingerprint Dive into the research topics of 'Impaired postexercise cardiovascular autonomic modulation in middle-aged women with type 2 diabetes'. Together they form a unique fingerprint.

Cite this