TY - JOUR
T1 - Impaired postexercise cardiovascular autonomic modulation in middle-aged women with type 2 diabetes
AU - Figueroa, Arturo
AU - Baynard, Tracy
AU - Fernhall, bo
AU - Carhart, Robert
AU - Kanaley, Jill A.
N1 - Funding Information:
This study was supported in part by NIDDK DK0631179–01 A2 Grant (P.I. Jill Kanaley, PhD).
PY - 2007/4
Y1 - 2007/4
N2 - Type 2 diabetes is associated with cardiovascular autonomic dysfunction. Postexercise autonomic modulation may be different in obese individuals with and without type 2 diabetes. We examined postexercise responses in nondiabetic and diabetic women aged 40–60 years. Hemodynamics, high-frequency and low-frequency of RR interval, low-frequency of systolic blood pressure variability and baroreflex sensitivity were evaluated before and after a 20 min walk at ~65% of VO2 peak in eight lean, 12 obese without type 2 diabetes and eight women with type 2 diabetes. Postexercise measurements were obtained at 10–15, 20–25 and 30–35 min. Systolic blood pressure decreased at 10 (P<0.001) and 20 min (P<0.01) in all groups. Total peripheral resistance decreased at 10 min in all women, but the subsequent increase at 20 min was greater (P<0.01) in lean than in diabetic women. Log-transformed low-frequency of systolic blood pressure increased (P<0.01) at 10 and 20 min in all women, but the increase at 10 min was smaller (P<0.05) in diabetic than in lean women. Heart rate was increased (P<0.001) at 10 min in all women and at 20 min in both obese groups. Both log-transformed high-frequency of RR interval and baroreflex sensitivity decreased at 10 and 20 min of recovery in all groups. A group-by-time interaction (P<0.05) was observed for heart rate and baroreflex sensitivity as a lower heart rate and higher baroreflex sensitivity were observed in lean women than in women with type 2 diabetes. Reduced postexercise baroreflex sensitivity and responses to autonomic cardiovascular activity contribute to an attenuated recovery of heart rate and total peripheral resistance after brisk walking in middle-aged obese women with type 2 diabetes.
AB - Type 2 diabetes is associated with cardiovascular autonomic dysfunction. Postexercise autonomic modulation may be different in obese individuals with and without type 2 diabetes. We examined postexercise responses in nondiabetic and diabetic women aged 40–60 years. Hemodynamics, high-frequency and low-frequency of RR interval, low-frequency of systolic blood pressure variability and baroreflex sensitivity were evaluated before and after a 20 min walk at ~65% of VO2 peak in eight lean, 12 obese without type 2 diabetes and eight women with type 2 diabetes. Postexercise measurements were obtained at 10–15, 20–25 and 30–35 min. Systolic blood pressure decreased at 10 (P<0.001) and 20 min (P<0.01) in all groups. Total peripheral resistance decreased at 10 min in all women, but the subsequent increase at 20 min was greater (P<0.01) in lean than in diabetic women. Log-transformed low-frequency of systolic blood pressure increased (P<0.01) at 10 and 20 min in all women, but the increase at 10 min was smaller (P<0.05) in diabetic than in lean women. Heart rate was increased (P<0.001) at 10 min in all women and at 20 min in both obese groups. Both log-transformed high-frequency of RR interval and baroreflex sensitivity decreased at 10 and 20 min of recovery in all groups. A group-by-time interaction (P<0.05) was observed for heart rate and baroreflex sensitivity as a lower heart rate and higher baroreflex sensitivity were observed in lean women than in women with type 2 diabetes. Reduced postexercise baroreflex sensitivity and responses to autonomic cardiovascular activity contribute to an attenuated recovery of heart rate and total peripheral resistance after brisk walking in middle-aged obese women with type 2 diabetes.
KW - autonomic nervous system
KW - baroreflex sensitivity
KW - heart rate variability
KW - obesity
KW - postexercise recovery
KW - type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=34247472734&partnerID=8YFLogxK
U2 - 10.1097/HJR.0b013e32801da10d
DO - 10.1097/HJR.0b013e32801da10d
M3 - Article
C2 - 17446802
AN - SCOPUS:34247472734
VL - 14
SP - 237
EP - 243
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
SN - 2047-4873
IS - 2
ER -