Immunotoxic effects of in vitro exposure of dolphin lymphocytes to Louisiana sweet crude oil and Corexit

Natasha White, Celine Godard, Sarah Webb, Gregory Bossart, Patricia Fair

Research output: Contribution to journalArticle

Abstract

ABSTRACT: The Deepwater Horizon oil spill was one of the worst environmental disasters on record in the United States. Response efforts to reduce the magnitude of the oil slick included the use of thousands of gallons of the chemical dispersant Corexit™ in surface and deep-water environments. The immunotoxicity of Louisiana sweet crude oil and the chemical dispersant Corexit was examined using lymphocyte proliferation (LP) and natural killer cell (NK) assays as measures of impact on the adaptive (LP) and innate (NK) immune response in bottlenose dolphins. Study results show that both high-energy mediaaccommodated fractions (MAF) and chemically enhanced MAF (CEMAF) mixtures modulate immune function. Following exposure to Louisiana sweet crude, both B- and T-cell proliferation of white blood cells was increased for all exposure concentrations, compared to control; however, this increasewas only significant for the 50%and 100%treatments. In contrast, exposure ofwhite blood cells to the C
Original languageEnglish
Pages (from-to)676-682
JournalJournal of Applied Toxicology
DOIs
StatePublished - Jun 2017

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