TY - JOUR
T1 - Immunity as a link between obesity and insulin resistance
AU - Kalupahana, Nishan S.
AU - Moustaid-Moussa, Naima
AU - Claycombe, Kate J.
PY - 2012/2
Y1 - 2012/2
N2 - Obesity is a major public health problem in the United States and worldwide. Further, obesity is causally linked to the pathogenesis of insulin resistance, metabolic syndrome and type-2 diabetes (T2D). A chronic low-grade inflammation occurring in adipose tissue is at least in part responsible for the obesity-induced insulin resistance. This adipose tissue inflammation is characterized by changes in immune cell populations giving rise to altered adipo/cytokine profiles, which in turn induces skeletal muscle and hepatic insulin resistance. Detailed molecular mechanisms of insulin resistance, adipose tissue inflammation and the implications of these findings on therapeutic strategies are discussed in this review.
AB - Obesity is a major public health problem in the United States and worldwide. Further, obesity is causally linked to the pathogenesis of insulin resistance, metabolic syndrome and type-2 diabetes (T2D). A chronic low-grade inflammation occurring in adipose tissue is at least in part responsible for the obesity-induced insulin resistance. This adipose tissue inflammation is characterized by changes in immune cell populations giving rise to altered adipo/cytokine profiles, which in turn induces skeletal muscle and hepatic insulin resistance. Detailed molecular mechanisms of insulin resistance, adipose tissue inflammation and the implications of these findings on therapeutic strategies are discussed in this review.
KW - Adipose tissue inflammation
KW - Insulin resistance
KW - Obesity
KW - Type-2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84655162215&partnerID=8YFLogxK
U2 - 10.1016/j.mam.2011.10.011
DO - 10.1016/j.mam.2011.10.011
M3 - Article
C2 - 22040698
AN - SCOPUS:84655162215
SN - 0098-2997
VL - 33
SP - 26
EP - 34
JO - Molecular Aspects of Medicine
JF - Molecular Aspects of Medicine
IS - 1
ER -