Abstract
A new, metal-free intermolecular formal [3 + 2] heterocyclization
between triethylammonium thiolates and aryl hydrazines has been
established by using the combination of 12 and 02 as efficient oxidation
sources, allowing a concise and low-cost access to new densely
functionalized 1,2,3-thiadiazoles with good to excellent yields. The
reaction showed a broad scope of substrates of both reactants and
attractive characteristics consisting of eco-friendly oxidants, flexible
structural modification, broad functional group compatibility, and mild
reaction conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 1258-1261 |
| Journal | Organic Letters |
| State | Published - Mar 2016 |