Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis

Wenhao Huang; Jingzhi Chen; Daocheng Hong; Wenxin Chen; Xu Cheng; Yuxi Tian; Guigen Li

doi:10.1021/acs.joc.7b02354

Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis

Wenhao Huang, Jingzhi Chen, Daocheng Hong, Wenxin Chen, Xu Cheng, Yuxi Tian, Guigen Li

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Visible-light-induced catalytic hydrophosphonodifluoromethylation of mono- and disubstituted alkenes using bromodifluoromethanephosphonate with a Hantzsch ester as the terminal reductant is reported. The combination of thiyl-radical catalysis with photoredox catalysis is important for achieving good chemoselectivity and high yields.

Original language	English
Pages (from-to)	578-587
Number of pages	10
Journal	Journal of Organic Chemistry
Volume	83
Issue number	2
DOIs	https://doi.org/10.1021/acs.joc.7b02354
State	Published - Jan 19 2018

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title = "Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis",

abstract = "Visible-light-induced catalytic hydrophosphonodifluoromethylation of mono- and disubstituted alkenes using bromodifluoromethanephosphonate with a Hantzsch ester as the terminal reductant is reported. The combination of thiyl-radical catalysis with photoredox catalysis is important for achieving good chemoselectivity and high yields.",

author = "Wenhao Huang and Jingzhi Chen and Daocheng Hong and Wenxin Chen and Xu Cheng and Yuxi Tian and Guigen Li",

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AU - Huang, Wenhao

AU - Chen, Jingzhi

AU - Hong, Daocheng

AU - Chen, Wenxin

AU - Cheng, Xu

AU - Tian, Yuxi

AU - Li, Guigen

PY - 2018/1/19

Y1 - 2018/1/19

N2 - Visible-light-induced catalytic hydrophosphonodifluoromethylation of mono- and disubstituted alkenes using bromodifluoromethanephosphonate with a Hantzsch ester as the terminal reductant is reported. The combination of thiyl-radical catalysis with photoredox catalysis is important for achieving good chemoselectivity and high yields.

AB - Visible-light-induced catalytic hydrophosphonodifluoromethylation of mono- and disubstituted alkenes using bromodifluoromethanephosphonate with a Hantzsch ester as the terminal reductant is reported. The combination of thiyl-radical catalysis with photoredox catalysis is important for achieving good chemoselectivity and high yields.

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JO - Journal of Organic Chemistry

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