Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis

Wenhao Huang; Jingzhi Chen; Daocheng Hong; Wenxin Chen; Xu Cheng; Yuxi Tian; Guigen Li

doi:10.1021/acs.joc.7b02354

Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis

Wenhao Huang, Jingzhi Chen, Daocheng Hong, Wenxin Chen, Xu Cheng, Yuxi Tian, Guigen Li

Chemistry and Biochemistry

Research output: Contribution to journal › Article

11 Scopus citations

Abstract

Visible-light-induced catalytic hydrophosphonodifluoromethylation of mono- and disubstituted alkenes using bromodifluoromethanephosphonate with a Hantzsch ester as the terminal reductant is reported. The combination of thiyl-radical catalysis with photoredox catalysis is important for achieving good chemoselectivity and high yields.

Original language	English
Pages (from-to)	578-587
Number of pages	10
Journal	Journal of Organic Chemistry
Volume	83
Issue number	2
DOIs	https://doi.org/10.1021/acs.joc.7b02354
State	Published - Jan 19 2018

Fingerprint

Cite this

Huang, W., Chen, J., Hong, D., Chen, W., Cheng, X., Tian, Y., & Li, G. (2018). Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis. Journal of Organic Chemistry, 83(2), 578-587. https://doi.org/10.1021/acs.joc.7b02354

@article{bfcceade37f142b699f68c04f7e2d0c6,

title = "Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis",

abstract = "Visible-light-induced catalytic hydrophosphonodifluoromethylation of mono- and disubstituted alkenes using bromodifluoromethanephosphonate with a Hantzsch ester as the terminal reductant is reported. The combination of thiyl-radical catalysis with photoredox catalysis is important for achieving good chemoselectivity and high yields.",

author = "Wenhao Huang and Jingzhi Chen and Daocheng Hong and Wenxin Chen and Xu Cheng and Yuxi Tian and Guigen Li",

year = "2018",

month = jan,

day = "19",

doi = "10.1021/acs.joc.7b02354",

language = "English",

volume = "83",

pages = "578--587",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

number = "2",

}

TY - JOUR

T1 - Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis

AU - Huang, Wenhao

AU - Chen, Jingzhi

AU - Hong, Daocheng

AU - Chen, Wenxin

AU - Cheng, Xu

AU - Tian, Yuxi

AU - Li, Guigen

PY - 2018/1/19

Y1 - 2018/1/19

N2 - Visible-light-induced catalytic hydrophosphonodifluoromethylation of mono- and disubstituted alkenes using bromodifluoromethanephosphonate with a Hantzsch ester as the terminal reductant is reported. The combination of thiyl-radical catalysis with photoredox catalysis is important for achieving good chemoselectivity and high yields.

AB - Visible-light-induced catalytic hydrophosphonodifluoromethylation of mono- and disubstituted alkenes using bromodifluoromethanephosphonate with a Hantzsch ester as the terminal reductant is reported. The combination of thiyl-radical catalysis with photoredox catalysis is important for achieving good chemoselectivity and high yields.

UR - http://www.scopus.com/inward/record.url?scp=85040841988&partnerID=8YFLogxK

U2 - 10.1021/acs.joc.7b02354

DO - 10.1021/acs.joc.7b02354

M3 - Article

C2 - 29260876

AN - SCOPUS:85040841988

VL - 83

SP - 578

EP - 587

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 2

ER -

Access to Document

10.1021/acs.joc.7b02354

Link to publication in Scopus