Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis

Wenhao Huang, Jingzhi Chen, Daocheng Hong, Wenxin Chen, Xu Cheng, Yuxi Tian, Guigen Li

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Visible-light-induced catalytic hydrophosphonodifluoromethylation of mono- and disubstituted alkenes using bromodifluoromethanephosphonate with a Hantzsch ester as the terminal reductant is reported. The combination of thiyl-radical catalysis with photoredox catalysis is important for achieving good chemoselectivity and high yields.

Original languageEnglish
Pages (from-to)578-587
Number of pages10
JournalJournal of Organic Chemistry
Issue number2
StatePublished - Jan 19 2018


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