Hybrid fabrication of biomimetic meniscus scaffold by 3D printing and parallel electrospinning

Dilshan Sooriyaarachchi, Jiaxin Wu, Aixin Feng, Maksud Islam, George Z. Tan

Research output: Contribution to journalConference articlepeer-review

4 Scopus citations

Abstract

Fabrication of biomimetic cell microenvironment closely resembling the native tissue is critical in regenerative medicine. This paper presents a novel meniscus tissue scaffold fabricated by a hybrid additive manufacturing technology to closely resemble the natural topology of the extracellular matrix. A skeletal scaffold was 3D printed and a layer of random or aligned polycaprolactone and collagen nanofibers were embedded between two frames. A compression test was performed to study the mechanical properties of the system. Human osteosarcoma cells were cultured in the scaffold for 7 days to evaluate the effect of scaffold microstructure on cell growth. With reinforced nanofibers, the hybrid scaffold showed superior compression strength compared to 3D printed scaffold without nanofibers. The hybrid scaffold induced the cells to organize into an aligned structure. The study shows the potential of hybrid bio fabrication process to be developed as a scalable platform for biomimetic scaffolds with patterned fibrous microstructure. It will facilitate the future development of clinical solutions for musculoskeletal tissue regeneration.

Original languageEnglish
Pages (from-to)528-534
Number of pages7
JournalProcedia Manufacturing
Volume34
DOIs
StatePublished - 2019
Event47th SME North American Manufacturing Research Conference, NAMRC 2019 - Erie, United States
Duration: Jun 10 2019Jun 14 2019

Keywords

  • 3D printing
  • Electrospinning
  • Hybrid biofabrication
  • Meniscus regeneration
  • Patterned fibrous microstructure
  • Tissue engineering

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