The aim of this study was to identify significant design features and textiles that would alleviate sensitivities for children with ASD. Small groups of randomized children with ASD and their parents participated in the study, pertaining to design features and textile related to characteristics of ASD. In the experiments, we tested weighted vests with three types of textiles (neoprene, wool, and denim) and newly developed prototypes with various textiles, including bamboo jersey, nylon with durable repellent, cotton, organic cotton, and polyester fleece. In this study, individuals with ASD exhibited certain tactile design preferences. Results from this study led to the development of sensory clothing products and provide evidence based therapeutic clothing design for individuals who have the everyday challenges posed by the characteristics of ASD.