How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1

Research output: Contribution to journalReview articlepeer-review

106 Scopus citations

Abstract

Pro-inflammatory cytokines are crucial for fighting infection and establishing immunity. Recently, other proteins, such as danger-associated molecular patterns (DAMPs), have also been appreciated for their role in inflammation and immunity. Following the formation and activation of multiprotein complexes, termed inflammasomes, two cytokines, IL-1β and IL-18, along with the DAMP High Mobility Group Box 1 (HMGB1), are released from cells. Although these proteins all lack classical secretion signals and are released by inflammasome activation, they each lead to different downstream consequences. This review examines how various inflammasomes promote the release of IL-1β, IL-18 and HMGB1 to combat pathogenic situations. Each of these effector molecules plays distinct roles during sterile inflammation, responding to viral, bacterial and parasite infection, and tailoring the innate immune response to specific threats.

Original languageEnglish
Pages (from-to)136-145
Number of pages10
JournalCytokine
Volume69
Issue number1
DOIs
StatePublished - Sep 2014

Keywords

  • Caspase-1
  • DAMP
  • Inflammasome
  • NLRP3

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