Historical overview of the effect of β-adrenergic agonists on beef cattle production

Bradley J. Johnson, Stephen B. Smith, Ki Yong Chung

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Postnatal muscle hypertrophy of beef cattle is the result of enhanced myofibrillar protein synthesis and reduced protein turnover. Skeletal muscle hypertrophy has been studied in cattle fed β-adrenergic agonists (β-AA), which are receptor-mediated enhancers of protein synthesis and inhibitors of protein degradation. Feeding β-AA to beef cattle increases longissimus muscle crosssectional area 6% to 40% compared to non-treated cattle. The β-AA have been reported to improve live animal performance, including average daily gain, feed efficiency, hot carcass weight, and dressing percentage. Treatment with β-AA increased mRNA concentration of the β2 or β1-adrenergic receptor and myosin heavy chain IIX in bovine skeletal muscle tissue. This review will examine the effects of skeletal muscle and adipose development with β-AA, and will interpret how the use of β-AA affects performance, body composition, and growth in beef cattle.

Original languageEnglish
Pages (from-to)757-766
Number of pages10
JournalAsian-Australasian Journal of Animal Sciences
Issue number5
StatePublished - May 2014


  • Beef cattle
  • Skeletal muscle
  • βAdrenergic agonists


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