Highly stereoselective synthesis of anti-tetrahydropyrimidine derivatives under microwave heating

Qian Wang, An Xiao Dai, Mian Shuai Yi, Bo Jiang, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticle

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New [3+3] heterocyclization has been established for the synthesis of anti-tetrahydropyrimidine derivatives. The reaction was conducted by reacting readily available and inexpensive starting materials, such as 4-arylidene-2-phenyloxazol-5(4H)-ones, and aryl amidines, under solvent-free condition and microwave irradiation. During the reaction processes, the selective construction of anti-tetrahydropyrimidine skeleton and two amide functions were readily achieved Via TEA-catalyzed ring-opening of oxazoles in a one-pot operation; in the meanwhile, lactone was converted into corresponding lactam in an intermolecular manner.

Original languageEnglish
Pages (from-to)411-424
Number of pages14
Issue number1
StatePublished - Dec 1 2012


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