Highly selective domino multicyclizations for forming polycyclic fused acridines and azaheterocyclic skeletons

Bo Jiang, Xue Wang, Hai Wei Xu, Man Su Tu, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Highly selective four-component domino multicyclizations for the synthesis of new fused acridines and azaheterocyclic skeletons have been established by mixing common reactants in isobutyric acid under microwave irradiation. The reactions proceeded at fast rates and were conducted to completion within 20-30 min. Up to seven new chemical bonds, four rings, and four stereocenters were assembled in a convenient one-pot operation. The resulting hexacyclic and pentacyclic fused acridines and their stereochemistry have been fully characterized and determined by X-ray structural analysis.

Original languageEnglish
Pages (from-to)1540-1543
Number of pages4
JournalOrganic Letters
Volume15
Issue number7
DOIs
StatePublished - Apr 5 2013

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