TY - JOUR
T1 - Highly permeable artificial water channels that can self-assemble into two-dimensional arrays
AU - Shen, Yue Xiao
AU - Si, Wen
AU - Erbakan, Mustafa
AU - Decker, Karl
AU - De Zorzi, Rita
AU - Saboe, Patrick O.
AU - Kang, You Jung
AU - Majd, Sheereen
AU - Butler, Peter J.
AU - Walz, Thomas
AU - Aksimentiev, Aleksei
AU - Hou, Jun Li
AU - Kumar, Manish
AU - Weitz, David A.
PY - 2015/8/11
Y1 - 2015/8/11
N2 - Bioinspired artificial water channels aim to combine the high permeability and selectivity of biological aquaporin (AQP) water channels with chemical stability. Here, we carefully characterized a class of artificial water channels, peptide-appended pillar[5]arenes (PAPs). The average single-channel osmotic water permeability for PAPs is 1.0(±0.3) × 10-14 cm3/s or 3.5(±1.0) × 108 water molecules per s, which is in the range of AQPs (3.440.3 × 108 water molecules per s) and their current synthetic analogs, carbon nanotubes (CNTs, 9.0 × 108 water molecules per s). This permeability is an order of magnitude higher than first-generation artificial water channels (20 to 107 water molecules per s). Furthermore, within lipid bilayers, PAP channels can self-assemble into 2D arrays. Relevant to permeable membrane design, the pore density of PAP channel arrays (2.6 × 105 pores per μm2) is two orders of magnitude higher than that of CNT membranes (0.12.5 × 103 pores per μm2). PAP channels thus combine the advantages of biological channels and CNTs and improve upon them through their relatively simple synthesis, chemical stability, and propensity to form arrays.
AB - Bioinspired artificial water channels aim to combine the high permeability and selectivity of biological aquaporin (AQP) water channels with chemical stability. Here, we carefully characterized a class of artificial water channels, peptide-appended pillar[5]arenes (PAPs). The average single-channel osmotic water permeability for PAPs is 1.0(±0.3) × 10-14 cm3/s or 3.5(±1.0) × 108 water molecules per s, which is in the range of AQPs (3.440.3 × 108 water molecules per s) and their current synthetic analogs, carbon nanotubes (CNTs, 9.0 × 108 water molecules per s). This permeability is an order of magnitude higher than first-generation artificial water channels (20 to 107 water molecules per s). Furthermore, within lipid bilayers, PAP channels can self-assemble into 2D arrays. Relevant to permeable membrane design, the pore density of PAP channel arrays (2.6 × 105 pores per μm2) is two orders of magnitude higher than that of CNT membranes (0.12.5 × 103 pores per μm2). PAP channels thus combine the advantages of biological channels and CNTs and improve upon them through their relatively simple synthesis, chemical stability, and propensity to form arrays.
KW - Artificial aquaporins
KW - Artificial water channels
KW - Peptide-appended pillar[5]arene
KW - Single-channel water permeability
KW - Two-dimensional arrays
UR - http://www.scopus.com/inward/record.url?scp=84938926612&partnerID=8YFLogxK
U2 - 10.1073/pnas.1508575112
DO - 10.1073/pnas.1508575112
M3 - Article
C2 - 26216964
AN - SCOPUS:84938926612
SN - 0027-8424
VL - 112
SP - 9810
EP - 9815
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 32
ER -