Highly diastereoselective aminobromination of β-methyl-β- nitrostyrenes with t-butyl N,N-dibromocarbamate/t-butyl carbamate as bromine/nitrogen sources

Sheng Chen, Jianlin Han, Guigen Li, Yi Pan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A facile and stereoselective aminobromination reaction of α,β-unsaturated nitro compounds with t-butyl N,N-dibromocarbamate/t- butyl carbamate as bromine/nitrogen sources was reported. This catalytic system could tolerate a wide scope of β-methyl-β-nitrostyrenes, resulting in good chemical yields and excellent regio- and stereoselectivities. Furthermore, the N-t-butoxycarbonyl protecting group could be easily cleaved to afford the free vicinal haloamines.

Original languageEnglish
Pages (from-to)2781-2784
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number22
DOIs
StatePublished - May 29 2013

Keywords

  • Keywords Aminobromination β-Methyl-β-nitrostyrenes t-Butyl N,N-dibromocarbamate Bromoamines Deprotection

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